A signal processing approach to the invetiation of the effects of age and smoking history on microvascular function
A signal processing approach to the invetiation of the effects of age and smoking history on microvascular function
We have used laser Doppler fluximetry [LDF] and signal processing to investigate the effects of smoking on microvascular function. Skin bloodflux was measured using a pin-head probe [Moor Instruments, UK] mounted in a 1 cm heating block before and during mild thermal warming to 43 °C, in 8 heavy smokers [mean 50 y; 19 cigarettes/day, 30pack years], 20 light smokers [23 y; 11/day, 4 pack years] and their age, sex and BMI matched non-smoking controls. Basal LDF analysed in the time domain was similar in all 4 groups [10–15 AU]. The increase in blood flux during the initial 10 min heating was attenuated in both light and heavy smokers vs controls [P<0.005]. Total hyperaemic response [AUC to 10 min] was also significantly attenuated in the heavy smokers [4 ± 2 vs 6 ± 2 x104 AU·sec] but not in the light smokers [8 ± 2 vs 10 ±4]. The LDF trace was analysed in the frequency domain using a fast Fourier transform and total spectral power together with the contribution of the frequency intervals between 0.01 and 2 Hz, calculated. Attenuation of the hyperaemic response in the heavy smokers was associated with a reduction in total spectral power of >40%, attributable to a reduction in spectral power around 0.01 Hz and 0.1 Hz [P<0.05]. These data suggest that the attenuation of the sustained hyperaemic response to thermal warming in long-term smokers is associated with a reduction in vasomotion and that this is in part the result of a reduced endothelial and smooth muscle cell activity. These changes are also evident in younger smokers with a shorter smoking history, suggesting that the vasodilatory response is impaired even at this early stage.
smoking, function
p.47
Avery, M.R.
45f11b91-6a6d-4676-85d2-1c601a976724
Voegeli, D.
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
August 2006
Avery, M.R.
45f11b91-6a6d-4676-85d2-1c601a976724
Voegeli, D.
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
Avery, M.R., Voegeli, D. and Clough, G.F.
(2006)
A signal processing approach to the invetiation of the effects of age and smoking history on microvascular function.
Journal of Vascular Research, 43 (Supplement 1), .
(doi:10.1159/000094939).
Abstract
We have used laser Doppler fluximetry [LDF] and signal processing to investigate the effects of smoking on microvascular function. Skin bloodflux was measured using a pin-head probe [Moor Instruments, UK] mounted in a 1 cm heating block before and during mild thermal warming to 43 °C, in 8 heavy smokers [mean 50 y; 19 cigarettes/day, 30pack years], 20 light smokers [23 y; 11/day, 4 pack years] and their age, sex and BMI matched non-smoking controls. Basal LDF analysed in the time domain was similar in all 4 groups [10–15 AU]. The increase in blood flux during the initial 10 min heating was attenuated in both light and heavy smokers vs controls [P<0.005]. Total hyperaemic response [AUC to 10 min] was also significantly attenuated in the heavy smokers [4 ± 2 vs 6 ± 2 x104 AU·sec] but not in the light smokers [8 ± 2 vs 10 ±4]. The LDF trace was analysed in the frequency domain using a fast Fourier transform and total spectral power together with the contribution of the frequency intervals between 0.01 and 2 Hz, calculated. Attenuation of the hyperaemic response in the heavy smokers was associated with a reduction in total spectral power of >40%, attributable to a reduction in spectral power around 0.01 Hz and 0.1 Hz [P<0.05]. These data suggest that the attenuation of the sustained hyperaemic response to thermal warming in long-term smokers is associated with a reduction in vasomotion and that this is in part the result of a reduced endothelial and smooth muscle cell activity. These changes are also evident in younger smokers with a shorter smoking history, suggesting that the vasodilatory response is impaired even at this early stage.
This record has no associated files available for download.
More information
Published date: August 2006
Additional Information:
24th Conference of the European Society for Microcirculation: Poster Session – PSF 2
Keywords:
smoking, function
Identifiers
Local EPrints ID: 61139
URI: http://eprints.soton.ac.uk/id/eprint/61139
ISSN: 1018-1172
PURE UUID: fb4c5819-2922-41fb-a219-fc938ed994ad
Catalogue record
Date deposited: 31 Mar 2009
Last modified: 16 Mar 2024 02:54
Export record
Altmetrics
Contributors
Author:
M.R. Avery
Author:
D. Voegeli
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics