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The effectiveness of glibenclamide in women with gestational diabetes

The effectiveness of glibenclamide in women with gestational diabetes
The effectiveness of glibenclamide in women with gestational diabetes
Background: Several studies have suggested that glibenclamide may be used safely and effectively in women with gestational diabetes mellitus (GDM). The aim of our study was to assess effectiveness and safety of glibenclamide for GDM in UK clinical practice. Methods: Women with GDM requiring pharmacological therapy were offered a choice of insulin or glibenclamide. Maternal and foetal outcomes were assessed in women treated with insulin (45) or glibenclamide (44) and also compared with women treated with diet alone (55). Results: Thirty-four (77%) achieved adequate glycaemic control with glibenclamide. Women choosing glibenclamide were more likely to be Asian and had higher fasting and 2-h glucose at diagnosis than those choosing insulin. There was no difference in maternal age or parity. Ten women treated with glibenclamide switched to insulin [inadequate control (7), unpredictable hypoglycaemia (1) and other reason (2)]. There was no difference in mode of birth, birth weight or birth weight centile between groups. One stillbirth occurred with glibenclamide. Glibenclamide treatment was associated with lower Apgar scores and increased neonatal jaundice. Neonatal hypoglycaemia occurred more frequently in babies of women treated with either glibenclamide or insulin. Conclusion: The use of glibenclamide in pregnancy is associated with adequate glycaemic control in 77% of women and achieved similar foetal outcomes to women treated with insulin.
foetus, gestational diabetes, glibenclamide, mother
1462-8902
906-911
Holt, R.I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Clarke, P.
9bf00ed7-b5fb-4b93-9eb7-46449b1ca69d
Parry, E.C.
32332bac-d53b-464f-a012-9f294365b470
Coleman, M.A.G.
83b02e3e-fc40-4bdc-8a34-a1789aff81a1
Holt, R.I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Clarke, P.
9bf00ed7-b5fb-4b93-9eb7-46449b1ca69d
Parry, E.C.
32332bac-d53b-464f-a012-9f294365b470
Coleman, M.A.G.
83b02e3e-fc40-4bdc-8a34-a1789aff81a1

Holt, R.I.G., Clarke, P., Parry, E.C. and Coleman, M.A.G. (2008) The effectiveness of glibenclamide in women with gestational diabetes. Diabetes, Obesity and Metabolism, 10 (10), 906-911. (doi:10.1111/j.1463-1326.2007.00828.x).

Record type: Article

Abstract

Background: Several studies have suggested that glibenclamide may be used safely and effectively in women with gestational diabetes mellitus (GDM). The aim of our study was to assess effectiveness and safety of glibenclamide for GDM in UK clinical practice. Methods: Women with GDM requiring pharmacological therapy were offered a choice of insulin or glibenclamide. Maternal and foetal outcomes were assessed in women treated with insulin (45) or glibenclamide (44) and also compared with women treated with diet alone (55). Results: Thirty-four (77%) achieved adequate glycaemic control with glibenclamide. Women choosing glibenclamide were more likely to be Asian and had higher fasting and 2-h glucose at diagnosis than those choosing insulin. There was no difference in maternal age or parity. Ten women treated with glibenclamide switched to insulin [inadequate control (7), unpredictable hypoglycaemia (1) and other reason (2)]. There was no difference in mode of birth, birth weight or birth weight centile between groups. One stillbirth occurred with glibenclamide. Glibenclamide treatment was associated with lower Apgar scores and increased neonatal jaundice. Neonatal hypoglycaemia occurred more frequently in babies of women treated with either glibenclamide or insulin. Conclusion: The use of glibenclamide in pregnancy is associated with adequate glycaemic control in 77% of women and achieved similar foetal outcomes to women treated with insulin.

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More information

Published date: October 2008
Keywords: foetus, gestational diabetes, glibenclamide, mother

Identifiers

Local EPrints ID: 61230
URI: http://eprints.soton.ac.uk/id/eprint/61230
ISSN: 1462-8902
PURE UUID: 9752a455-df2d-45a5-9faa-d1afdef99362
ORCID for R.I.G. Holt: ORCID iD orcid.org/0000-0001-8911-6744

Catalogue record

Date deposited: 26 Sep 2008
Last modified: 16 Mar 2024 03:19

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Contributors

Author: R.I.G. Holt ORCID iD
Author: P. Clarke
Author: E.C. Parry
Author: M.A.G. Coleman

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