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Radiological outcome of very prematurely born infants randomised to high frequency oscillatory or conventional ventilation

Radiological outcome of very prematurely born infants randomised to high frequency oscillatory or conventional ventilation
Radiological outcome of very prematurely born infants randomised to high frequency oscillatory or conventional ventilation
The appearance of the chest radiograph (CXR) at 28 days after birth or 36 weeks post-menstrual age (PMA) has been shown to be predictive of respiratory symptoms at follow-up. The aim of this study was to determine whether the CXR appearance at 28 days or 36 weeks PMA differed according to the ventilatory mode used in the perinatal period. CXRs were routinely obtained at 28 days and 36 weeks PMA from infants entered into a multicentre randomised trial (UKOS) comparing high frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation (CMV); the ventilation allocation mode had been instituted within 60 min of birth. The CXRs were assessed using a scoring system (maximum score 8) for the presence of fibrosis/interstitial shadows, cystic elements and hyperinflation. A total of 487 infants, median gestational age 26+5 weeks (range 23-28+6 weeks) and birth weight 865 g (range 428-1459 g) who had had a CXR taken at 28 days and/or 36 weeks PMA. No significant differences were found between the total CXR scores of the two groups either at 28 days or 36 weeks PMA (mean scores 3.2 HFOV versus 3.5 CMV, 95%CI for difference -0.66 to 0.06, P=0.11 at 28 days and mean scores 3.5 HFOV versus 3.6 CMV, 95% for difference -0.49 to 0.29, P=0.61 at 36 weeks PMA). CONCLUSION: These results are consistent with high frequency oscillatory ventilation and conventional mechanical ventilation having similar effects on pulmonary function in very prematurely born infants.
high-frequency ventilation, premature, birth weight, infant, birth, children, weight, chronic disease, research support, multicenter studies, comparative study, newborn, trial, chest radiograph
0340-6199
671-674
Greenough, Anne
5fb7521d-ae58-4a58-9a0b-deddcf1647c2
Limb, Elizabeth
13283891-a300-4755-8ea0-98d4b1931b93
Marlow, Neil
0c6bd3b0-464b-4f04-8dd3-72517da5cbd7
Peacock, Janet L.
1cb1242c-7606-4f8e-86d0-d3cd2ceff782
Calvert, Sandra
14a9b831-27b8-4208-9305-185493158023
Greenough, Anne
5fb7521d-ae58-4a58-9a0b-deddcf1647c2
Limb, Elizabeth
13283891-a300-4755-8ea0-98d4b1931b93
Marlow, Neil
0c6bd3b0-464b-4f04-8dd3-72517da5cbd7
Peacock, Janet L.
1cb1242c-7606-4f8e-86d0-d3cd2ceff782
Calvert, Sandra
14a9b831-27b8-4208-9305-185493158023

Greenough, Anne, Limb, Elizabeth, Marlow, Neil, Peacock, Janet L. and Calvert, Sandra (2004) Radiological outcome of very prematurely born infants randomised to high frequency oscillatory or conventional ventilation. European Journal of Pediatrics, 163 (11), 671-674. (doi:10.1007/s00431-004-1526-6).

Record type: Article

Abstract

The appearance of the chest radiograph (CXR) at 28 days after birth or 36 weeks post-menstrual age (PMA) has been shown to be predictive of respiratory symptoms at follow-up. The aim of this study was to determine whether the CXR appearance at 28 days or 36 weeks PMA differed according to the ventilatory mode used in the perinatal period. CXRs were routinely obtained at 28 days and 36 weeks PMA from infants entered into a multicentre randomised trial (UKOS) comparing high frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation (CMV); the ventilation allocation mode had been instituted within 60 min of birth. The CXRs were assessed using a scoring system (maximum score 8) for the presence of fibrosis/interstitial shadows, cystic elements and hyperinflation. A total of 487 infants, median gestational age 26+5 weeks (range 23-28+6 weeks) and birth weight 865 g (range 428-1459 g) who had had a CXR taken at 28 days and/or 36 weeks PMA. No significant differences were found between the total CXR scores of the two groups either at 28 days or 36 weeks PMA (mean scores 3.2 HFOV versus 3.5 CMV, 95%CI for difference -0.66 to 0.06, P=0.11 at 28 days and mean scores 3.5 HFOV versus 3.6 CMV, 95% for difference -0.49 to 0.29, P=0.61 at 36 weeks PMA). CONCLUSION: These results are consistent with high frequency oscillatory ventilation and conventional mechanical ventilation having similar effects on pulmonary function in very prematurely born infants.

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More information

Published date: November 2004
Keywords: high-frequency ventilation, premature, birth weight, infant, birth, children, weight, chronic disease, research support, multicenter studies, comparative study, newborn, trial, chest radiograph

Identifiers

Local EPrints ID: 61803
URI: http://eprints.soton.ac.uk/id/eprint/61803
ISSN: 0340-6199
PURE UUID: 63c4d362-03f3-429b-a6c1-10d032985f19

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Date deposited: 10 Sep 2008
Last modified: 15 Mar 2024 11:28

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Contributors

Author: Anne Greenough
Author: Elizabeth Limb
Author: Neil Marlow
Author: Janet L. Peacock
Author: Sandra Calvert

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