Association between antipsychotic drugs and diabetes
Association between antipsychotic drugs and diabetes
The link between atypical antipsychotic drugs and the development of diabetes has been hotly debated in the literature. In this review, we attempt to classify the various types of data published and presented in a hierarchical basis. Case reports and retrospective pharmacoepidemiological studies suggest that both conventional and atypical antipsychotic medications are associated with an increased risk of glucose abnormalities or diabetes. Prospective data examining the relationship between atypical antipsychotic drugs and diabetes began to emerge in 2003 and are much less conclusive. Estimates of the attributable risk associated with atypical antipsychotic drugs are low. The few studies that have included a placebo group suggest that we cannot necessarily blame antipsychotic medication when diabetes develops in an individual with schizophrenia.
atypical antipsychotic drugs, diabetes, insulin resistance, schizophrenia
125-135
Holt, Richard I.
d54202e1-fcf6-4a17-a320-9f32d7024393
Peveler, Robert C.
93198224-78d9-4c1f-9c07-fdecfa69cf96
25 April 2006
Holt, Richard I.
d54202e1-fcf6-4a17-a320-9f32d7024393
Peveler, Robert C.
93198224-78d9-4c1f-9c07-fdecfa69cf96
Holt, Richard I. and Peveler, Robert C.
(2006)
Association between antipsychotic drugs and diabetes.
Diabetes, Obesity and Metabolism, 8 (2), .
(doi:10.1111/j.1463-1326.2005.00495.x).
Abstract
The link between atypical antipsychotic drugs and the development of diabetes has been hotly debated in the literature. In this review, we attempt to classify the various types of data published and presented in a hierarchical basis. Case reports and retrospective pharmacoepidemiological studies suggest that both conventional and atypical antipsychotic medications are associated with an increased risk of glucose abnormalities or diabetes. Prospective data examining the relationship between atypical antipsychotic drugs and diabetes began to emerge in 2003 and are much less conclusive. Estimates of the attributable risk associated with atypical antipsychotic drugs are low. The few studies that have included a placebo group suggest that we cannot necessarily blame antipsychotic medication when diabetes develops in an individual with schizophrenia.
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Published date: 25 April 2006
Keywords:
atypical antipsychotic drugs, diabetes, insulin resistance, schizophrenia
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Local EPrints ID: 62410
URI: http://eprints.soton.ac.uk/id/eprint/62410
ISSN: 1462-8902
PURE UUID: 55ba8ac0-d1e0-4432-bbbc-3dedbe6ec8f5
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Date deposited: 12 Sep 2008
Last modified: 16 Mar 2024 03:19
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