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Risk factors for respiratory morbidity in infancy after very premature birth

Risk factors for respiratory morbidity in infancy after very premature birth
Risk factors for respiratory morbidity in infancy after very premature birth
Objectives: To determine the occurrence of respiratory morbidity during infancy after very premature birth and to identify risk factors. Design: Prospective follow up study. Setting: The United Kingdom oscillation study. Patients: 492 infants, all born before 29 weeks gestation. Interventions: Structured questionnaires were completed by local paediatricians when the infants were seen in outpatients at 6 and 12 months of age corrected for prematurity. Main outcome measures: Cough, wheeze, and treatment requirements and the composite measure of respiratory morbidity (cough, frequent cough, cough without infection, wheeze, frequent wheeze, wheeze without infection, and use of chest medicine) and their relation to 13 possible explanatory variables. Results: At 6 and 12 months of corrected age, 27% of the infants coughed and 6% had frequent (more than once a week) cough, and 20% and 3% respectively had wheeze or frequent wheeze. At 6 and 12 months, 14% of infants had taken bronchodilators and 8% inhaled steroids. After adjustment for multiple outcome testing, four factors were associated with increased respiratory morbidity: male sex, oxygen dependency at 36 weeks postmenstrual age, having older siblings aged less than 5 years, and living in rented accommodation. Conclusions: Male infants are particularly vulnerable to respiratory morbidity in infancy after very premature birth. it is important to identify a safe and effective strategy to prevent chronic oxygen dependency
prematurity, oxygen dependency, respiratory morbidity, wheeze
1359-2998
F320-F323
Greenough, A
75a1b8a8-773e-49bd-b038-f9e7bfae1b2a
Limb, E
f9d73ea8-cfe4-4667-9fa3-e8152d656606
Marston, L
be443e21-4602-460e-a9b8-b642acba83c8
Marlow, N
f119cba2-1811-4906-a2d7-474e1da2c043
Calvert, S
5eb24fb2-57be-4cc5-9e34-1cbcd2c31189
Peacock, J
359ddf12-8d85-41d0-88a1-21faa36dabc2
Greenough, A
75a1b8a8-773e-49bd-b038-f9e7bfae1b2a
Limb, E
f9d73ea8-cfe4-4667-9fa3-e8152d656606
Marston, L
be443e21-4602-460e-a9b8-b642acba83c8
Marlow, N
f119cba2-1811-4906-a2d7-474e1da2c043
Calvert, S
5eb24fb2-57be-4cc5-9e34-1cbcd2c31189
Peacock, J
359ddf12-8d85-41d0-88a1-21faa36dabc2

Greenough, A, Limb, E, Marston, L, Marlow, N, Calvert, S and Peacock, J (2005) Risk factors for respiratory morbidity in infancy after very premature birth. Archives of Disease in Childhood. Fetal and Neonatal Edition, 90 (4), F320-F323. (doi:10.1136/adc.2004.062018).

Record type: Article

Abstract

Objectives: To determine the occurrence of respiratory morbidity during infancy after very premature birth and to identify risk factors. Design: Prospective follow up study. Setting: The United Kingdom oscillation study. Patients: 492 infants, all born before 29 weeks gestation. Interventions: Structured questionnaires were completed by local paediatricians when the infants were seen in outpatients at 6 and 12 months of age corrected for prematurity. Main outcome measures: Cough, wheeze, and treatment requirements and the composite measure of respiratory morbidity (cough, frequent cough, cough without infection, wheeze, frequent wheeze, wheeze without infection, and use of chest medicine) and their relation to 13 possible explanatory variables. Results: At 6 and 12 months of corrected age, 27% of the infants coughed and 6% had frequent (more than once a week) cough, and 20% and 3% respectively had wheeze or frequent wheeze. At 6 and 12 months, 14% of infants had taken bronchodilators and 8% inhaled steroids. After adjustment for multiple outcome testing, four factors were associated with increased respiratory morbidity: male sex, oxygen dependency at 36 weeks postmenstrual age, having older siblings aged less than 5 years, and living in rented accommodation. Conclusions: Male infants are particularly vulnerable to respiratory morbidity in infancy after very premature birth. it is important to identify a safe and effective strategy to prevent chronic oxygen dependency

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More information

Submitted date: 2005
Published date: July 2005
Keywords: prematurity, oxygen dependency, respiratory morbidity, wheeze
Organisations: Community Clinical Sciences

Identifiers

Local EPrints ID: 72640
URI: http://eprints.soton.ac.uk/id/eprint/72640
ISSN: 1359-2998
PURE UUID: 362cc8d9-566c-4bc6-aae1-340a23464fd0

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Date deposited: 23 Feb 2010
Last modified: 13 Mar 2024 21:35

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Contributors

Author: A Greenough
Author: E Limb
Author: L Marston
Author: N Marlow
Author: S Calvert
Author: J Peacock

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