Potential directions for drug development for osteoarthritis
Potential directions for drug development for osteoarthritis
Background: osteoarthritis (OA) is a frustrating disease for both patient and physician because neither cause nor cure is known and there are currently no disease-modifying drugs. Objective: To review current therapeutic approaches as well as new findings regarding OA pathoetiology that could form the basis of future direction for the development of drugs to prevent or slow down disease progression. Methods: After reviewing disease progression in human OA, as demonstrated by histological analyses, the reasons for cartilage erosion are explored and possible therapeutic approaches are highlighted. Results/conclusions: OA may be an epigenetic disease. This new concept can explain many aspects of the disease and provide reasons why therapeutic approaches until now have met with little success.
aggrecanases, articular chondrocyte, DNA methylation, drug development, epigenetics, matrix metalloproteases, osteoarthritis, pathoetiology
475-486
Roach, Helmtrud I.
ca2ff1f4-1ada-4c56-9097-cd27ca4d199e
May 2008
Roach, Helmtrud I.
ca2ff1f4-1ada-4c56-9097-cd27ca4d199e
Roach, Helmtrud I.
(2008)
Potential directions for drug development for osteoarthritis.
Expert Opinion on Drug Discovery, 3 (5), .
(doi:10.1517/17460441.3.5.475).
Abstract
Background: osteoarthritis (OA) is a frustrating disease for both patient and physician because neither cause nor cure is known and there are currently no disease-modifying drugs. Objective: To review current therapeutic approaches as well as new findings regarding OA pathoetiology that could form the basis of future direction for the development of drugs to prevent or slow down disease progression. Methods: After reviewing disease progression in human OA, as demonstrated by histological analyses, the reasons for cartilage erosion are explored and possible therapeutic approaches are highlighted. Results/conclusions: OA may be an epigenetic disease. This new concept can explain many aspects of the disease and provide reasons why therapeutic approaches until now have met with little success.
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Expert_Opinion_08.pdf
- Accepted Manuscript
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Published date: May 2008
Additional Information:
Invited review
Keywords:
aggrecanases, articular chondrocyte, DNA methylation, drug development, epigenetics, matrix metalloproteases, osteoarthritis, pathoetiology
Identifiers
Local EPrints ID: 72830
URI: http://eprints.soton.ac.uk/id/eprint/72830
ISSN: 1746-0441
PURE UUID: 20560bc9-74b4-48db-b246-de895afb8b47
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Date deposited: 23 Feb 2010
Last modified: 13 Mar 2024 21:42
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Author:
Helmtrud I. Roach
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