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Use of organic nitrates and the risk of hip fracture: a population-based case-control study

Use of organic nitrates and the risk of hip fracture: a population-based case-control study
Use of organic nitrates and the risk of hip fracture: a population-based case-control study
Context: Use of organic nitrates has been associated with increased bone mineral density. Moreover, a large Danish case-control study reported a decreased fracture risk. However, the association with duration of nitrate use, dose frequency, and impact of discontinuation has not been extensively studied. Objective: Our objective was to evaluate the association between organic nitrates and hip fracture risk. Methods: A case-control study was conducted using the Dutch PHARMO Record Linkage System (1991-2002, n = 6,763 hip fracture cases and 26,341 controls). Cases had their first admission for hip fracture, whereas controls had not sustained any fracture after enrollment. Current users of organic nitrates were patients who had received a prescription within 90 d before the index date. The analyses were adjusted for disease and drug history. Results: Current use of nitrates was not associated with a decreased risk of hip fracture [adjusted odds ratio (OR) = 0.93; 95% confidence interval (CI) = 0.83-1.04]. Those who used as-needed medication only had a lower risk of hip fracture (adjusted OR = 0.83; 95% CI = 0.63-1.08) compared with users of maintenance medication only (adjusted OR = 1.17; 95% CI = 0.97-1.40). No association was found between duration of nitrate use and fracture risk. Conclusions: Our overall analyses showed that risk of a hip fracture was significantly lower among users of as-needed organic nitrates, when compared with users of maintenance medication. Our analyses of hip fracture risks with duration of use did not further support a beneficial effect of organic nitrates on hip fracture, although residual confounding may have masked beneficial effects.
8756-3282
p.S397
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
Lalmohamed, A.
b3bef1c3-1d0f-4e3d-b999-a00b16aff528
van Staa, T.
7e263d59-ecc2-41f2-8b20-3f934d09c2c9
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Souverein, P.
0f00e35b-57c4-47ca-99a4-0b307faa215d
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Rejnmark, L.
d3be04fd-4c6f-46fd-9f6a-1a6a19bd547c
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Vestergaard, P.
b00ba0f8-a9b7-45f1-a0c7-579fec88b556
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
Lalmohamed, A.
b3bef1c3-1d0f-4e3d-b999-a00b16aff528
van Staa, T.
7e263d59-ecc2-41f2-8b20-3f934d09c2c9
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Souverein, P.
0f00e35b-57c4-47ca-99a4-0b307faa215d
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Rejnmark, L.
d3be04fd-4c6f-46fd-9f6a-1a6a19bd547c
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Vestergaard, P.
b00ba0f8-a9b7-45f1-a0c7-579fec88b556
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613

Pouwels, S., Lalmohamed, A., van Staa, T., Cooper, C., Souverein, P., Leufkens, H.G., Rejnmark, L., de Boer, A., Vestergaard, P. and de Vries, F. (2009) Use of organic nitrates and the risk of hip fracture: a population-based case-control study. [in special issue: ECTS 2009: 36th European Symposium on Calcified Tissues] Bone, 44, supplement 2, p.S397. (doi:10.1016/j.bone.2009.03.293). (PMID:20130070)

Record type: Article

Abstract

Context: Use of organic nitrates has been associated with increased bone mineral density. Moreover, a large Danish case-control study reported a decreased fracture risk. However, the association with duration of nitrate use, dose frequency, and impact of discontinuation has not been extensively studied. Objective: Our objective was to evaluate the association between organic nitrates and hip fracture risk. Methods: A case-control study was conducted using the Dutch PHARMO Record Linkage System (1991-2002, n = 6,763 hip fracture cases and 26,341 controls). Cases had their first admission for hip fracture, whereas controls had not sustained any fracture after enrollment. Current users of organic nitrates were patients who had received a prescription within 90 d before the index date. The analyses were adjusted for disease and drug history. Results: Current use of nitrates was not associated with a decreased risk of hip fracture [adjusted odds ratio (OR) = 0.93; 95% confidence interval (CI) = 0.83-1.04]. Those who used as-needed medication only had a lower risk of hip fracture (adjusted OR = 0.83; 95% CI = 0.63-1.08) compared with users of maintenance medication only (adjusted OR = 1.17; 95% CI = 0.97-1.40). No association was found between duration of nitrate use and fracture risk. Conclusions: Our overall analyses showed that risk of a hip fracture was significantly lower among users of as-needed organic nitrates, when compared with users of maintenance medication. Our analyses of hip fracture risks with duration of use did not further support a beneficial effect of organic nitrates on hip fracture, although residual confounding may have masked beneficial effects.

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e-pub ahead of print date: 23 May 2009
Published date: June 2009

Identifiers

Local EPrints ID: 72891
URI: http://eprints.soton.ac.uk/id/eprint/72891
ISSN: 8756-3282
PURE UUID: fa5bd99b-30cf-4415-b060-c6b689cc02c0
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 24 Feb 2010
Last modified: 18 Mar 2024 02:44

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Contributors

Author: S. Pouwels
Author: A. Lalmohamed
Author: T. van Staa
Author: C. Cooper ORCID iD
Author: P. Souverein
Author: H.G. Leufkens
Author: L. Rejnmark
Author: A. de Boer
Author: P. Vestergaard
Author: F. de Vries

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