Immunotherapy for neuroblastoma: turning promise into reality.
Immunotherapy for neuroblastoma: turning promise into reality.
Neuroblastoma is one of the commonest and most aggressive paediatric malignancies. The majority of children present with metastatic disease for which long-term survival remains poor despite intensive multi-modal therapies. Toxicity from current treatment regimes is already significant, and there is little room to further intensify therapy. Alternative treatment strategies are therefore needed in order to improve survival. Immunotherapy is an attractive therapeutic option for these children as it potentially offers a much more specific and less toxic treatment than conventional therapies. This review discusses the different immunotherapy strategies that may be useful in neuroblastoma, their advantages and disadvantages and the challenges that need to be overcome to successfully use them clinically.
immunology, immunotherapy, neuroblastoma
931-940
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Kohler, Janice A.
b37f534f-93bc-412e-8631-afb326e0707f
9 July 2009
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Kohler, Janice A.
b37f534f-93bc-412e-8631-afb326e0707f
Gray, Juliet C. and Kohler, Janice A.
(2009)
Immunotherapy for neuroblastoma: turning promise into reality.
Pediatric Blood and Cancer, 53 (6), .
(doi:10.1002/pbc.22153).
Abstract
Neuroblastoma is one of the commonest and most aggressive paediatric malignancies. The majority of children present with metastatic disease for which long-term survival remains poor despite intensive multi-modal therapies. Toxicity from current treatment regimes is already significant, and there is little room to further intensify therapy. Alternative treatment strategies are therefore needed in order to improve survival. Immunotherapy is an attractive therapeutic option for these children as it potentially offers a much more specific and less toxic treatment than conventional therapies. This review discusses the different immunotherapy strategies that may be useful in neuroblastoma, their advantages and disadvantages and the challenges that need to be overcome to successfully use them clinically.
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Submitted date: November 2008
Published date: 9 July 2009
Keywords:
immunology, immunotherapy, neuroblastoma
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Local EPrints ID: 73091
URI: http://eprints.soton.ac.uk/id/eprint/73091
ISSN: 1545-5009
PURE UUID: 65a6a1ed-d0f9-4d96-aa64-e1dc2a4b1588
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Date deposited: 01 Mar 2010
Last modified: 14 Mar 2024 02:48
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Author:
Janice A. Kohler
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