The University of Southampton
University of Southampton Institutional Repository

Maternal muscle mass may influence system A activity in human placenta

Maternal muscle mass may influence system A activity in human placenta
Maternal muscle mass may influence system A activity in human placenta
During pregnancy, nutrient partitioning between the mother and fetus must balance promoting fetal survival and maintaining nutritional status of the mother for her health and future fertility. The nutritional status of the pregnant woman, reflected in her body composition, may affect placental function with consequences for fetal development.

We investigated the relationship between maternal body composition and placental system A amino acid transporter activity in 103 term placentas from Southampton Women's Survey pregnancies.

Placental system A activity was measured as Na+-dependent uptake of 10 ?mol/L 14C-methylaminoisobutyric acid (a system A specific amino acid analogue) in placental villous fragments. Maternal body composition was measured at enrolment pre-pregnancy; in 45 infants neonatal body composition was measured using dual-energy x-ray absorptiometry.

Term placental system A activity was lower in women with smaller pre-pregnancy upper arm muscle area (r = 0.27, P = 0.007), but was not related to maternal fat mass. System A activity was lower in mothers who reported undertaking strenuous exercise (24.6 vs 29.7 pmol/mg/15 min in sedentary women, P = 0.03), but was not associated with other maternal lifestyle factors.

Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. This alteration may affect fetal development, altering fetal body composition, with long-term consequences
placenta, maternal body composition, amino acid transport, fetal
0143-4004
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Greenwood, S.L.
09a72af7-5c7f-47f0-a4ba-89887758d6e7
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Crozier, S.R.
a97b1967-f6af-413a-8eb0-69fa25534d68
Verrall, L.
2f7a725b-e3f1-4321-b1c8-b1652a82c414
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Cameron, I.T.
f7595539-efa6-4687-b161-e1e93ff710f2
Cooper, C
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sibley, C.P.
6e4ffcd0-f4b5-41c4-8360-9d78b9e9156c
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Greenwood, S.L.
09a72af7-5c7f-47f0-a4ba-89887758d6e7
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Crozier, S.R.
a97b1967-f6af-413a-8eb0-69fa25534d68
Verrall, L.
2f7a725b-e3f1-4321-b1c8-b1652a82c414
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Cameron, I.T.
f7595539-efa6-4687-b161-e1e93ff710f2
Cooper, C
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sibley, C.P.
6e4ffcd0-f4b5-41c4-8360-9d78b9e9156c
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

Lewis, R.M., Greenwood, S.L., Cleal, J.K., Crozier, S.R., Verrall, L., Inskip, H.M., Cameron, I.T., Cooper, C, Sibley, C.P., Hanson, M.A. and Godfrey, K.M. (2010) Maternal muscle mass may influence system A activity in human placenta. Placenta, 31 (5). (doi:10.1016/j.placenta.2010.02.001).

Record type: Article

Abstract

During pregnancy, nutrient partitioning between the mother and fetus must balance promoting fetal survival and maintaining nutritional status of the mother for her health and future fertility. The nutritional status of the pregnant woman, reflected in her body composition, may affect placental function with consequences for fetal development.

We investigated the relationship between maternal body composition and placental system A amino acid transporter activity in 103 term placentas from Southampton Women's Survey pregnancies.

Placental system A activity was measured as Na+-dependent uptake of 10 ?mol/L 14C-methylaminoisobutyric acid (a system A specific amino acid analogue) in placental villous fragments. Maternal body composition was measured at enrolment pre-pregnancy; in 45 infants neonatal body composition was measured using dual-energy x-ray absorptiometry.

Term placental system A activity was lower in women with smaller pre-pregnancy upper arm muscle area (r = 0.27, P = 0.007), but was not related to maternal fat mass. System A activity was lower in mothers who reported undertaking strenuous exercise (24.6 vs 29.7 pmol/mg/15 min in sedentary women, P = 0.03), but was not associated with other maternal lifestyle factors.

Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. This alteration may affect fetal development, altering fetal body composition, with long-term consequences

This record has no associated files available for download.

More information

Published date: May 2010
Keywords: placenta, maternal body composition, amino acid transport, fetal

Identifiers

Local EPrints ID: 73301
URI: http://eprints.soton.ac.uk/id/eprint/73301
ISSN: 0143-4004
PURE UUID: cea58367-c10e-476f-b2e7-54321b17d6f5
ORCID for R.M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104
ORCID for J.K. Cleal: ORCID iD orcid.org/0000-0001-7978-4327
ORCID for H.M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for I.T. Cameron: ORCID iD orcid.org/0000-0002-4875-267X
ORCID for C Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for M.A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 04 Mar 2010
Last modified: 18 Mar 2024 02:54

Export record

Altmetrics

Contributors

Author: R.M. Lewis ORCID iD
Author: S.L. Greenwood
Author: J.K. Cleal ORCID iD
Author: S.R. Crozier
Author: L. Verrall
Author: H.M. Inskip ORCID iD
Author: I.T. Cameron ORCID iD
Author: C Cooper ORCID iD
Author: C.P. Sibley
Author: M.A. Hanson ORCID iD
Author: K.M. Godfrey ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×