MicroRNAs: key players in carcinogenesis and novel therapeutic targets
MicroRNAs: key players in carcinogenesis and novel therapeutic targets
MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype.
The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.
MicroRNA, molecular profiling, cancer, clinical utility
339-347
Mirnezami, A. H. F
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Pickard, K.
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Zhang, L.
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Primrose, J. N.
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Packham, G.
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April 2008
Mirnezami, A. H. F
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Pickard, K.
e5188669-dff1-49c7-9c6f-8122b0c74bd9
Zhang, L.
1170f035-b8d0-490c-ac24-ee05105011a7
Primrose, J. N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394
Mirnezami, A. H. F, Pickard, K., Zhang, L., Primrose, J. N. and Packham, G.
(2008)
MicroRNAs: key players in carcinogenesis and novel therapeutic targets.
European Journal of Surgical Oncology, 35 (4), .
(doi:10.1016/j.ejso.2008.06.006).
Abstract
MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype.
The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.
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Published date: April 2008
Keywords:
MicroRNA, molecular profiling, cancer, clinical utility
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Local EPrints ID: 79414
URI: http://eprints.soton.ac.uk/id/eprint/79414
ISSN: 0748-7983
PURE UUID: 6515c80b-5f7e-4285-b7e6-e390ee3e31e7
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Date deposited: 15 Mar 2010
Last modified: 14 Mar 2024 02:44
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Author:
K. Pickard
Author:
L. Zhang
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