Browse by Divisions pre August 2011

Asher, I., Boner, A., Chuchalin, A., Custovic, A., Dagli, E., Haus, M., Hemmo-Lotem, M., Holgate, S.T., Holt, P.G., Host, A., Iikura, I., Johansson, S.G., Kowalski, M.L., Naspitz, C.K., Odhiambo, J., Vichyanond, P., Volovitz, B., Wahn, U., Warner, J.O., Weiss, K. and Zhong, N.S. (2000) Prevention of allergy and asthma: interim report. Allergy, 55, (11), 1069-1088. (doi:10.1034/j.1398-9995.2000.00001.x).

Babu, K.S. and Holgate, S.T. (2000) Potential and novel therapies for asthma. The Journal of the Association of Physicians of India, 48, (11), 1096-1102.

Bacon, Annette S., Ahluwalia, Poonam, Irani, Anne-Marie, Schwartz, Lawrence B., Holgate, Stephen T., Church, Martin K. and McGill, James I. (2000) Tear and conjunctival changes during the allergen-induced early-and late-phase responses. Journal of Allergy and Clinical Immunology, 106, (5), 948-954. (doi:10.1067/mai.2000.110930).

Bardin, P.G., Fraenkel, D.J.G., VanSchalkwyk, E.M., Holgate, S.T. and Johnston, S.L. (2000) Peak expiratory flow changes during experimental rhinovirus infection. European Respiratory Journal, 16, (5), 980-985.

Bjermer, L., Bisgaard, H., Bousquet, J., Fabbri, L.M., Greening, A., Haahtela, T., Holgate, S.T., Picado, C. and Leff, J.A. (2000) Montelukast or salmeterol combined with an inhaled steroid in adult asthma: design and rationale of a randomized, double-blind comparative study (the IMPACT Investigation of Montelukast as a Partner Agent for Complementary Therapy-trial). Respiratory Medicine, 94, (6), 612-621. (doi:10.1053/rmed.2000.0806).

Bryan, Shannon A., O'Connor, Brian J., Matti, Salah, Leckie, Margaret J., Kanabar, Varsha, Khan, Jamey, Warrington, Steven J., Renzetti, Louis, Rames, Alexis, Bock, JuergenA., Boyce, Malcolm J., Hansel, Trevor T., Holgate, Stephen T. and Barnes, Peter J. (2000) Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet, 356, (9248), 2149-2153. (doi:10.1016/S0140-6736(00)03497-8).

Christodoulides, Myron, Everson, J. Sylvia, Liu, Bin L., Lambden, Paul R., Watt, Peter J., Thomas, Eric J. and Heckels, John E. (2000) Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein. Molecular Microbiology, 35, (1), 32-43. (doi:10.1046/j.1365-2958.2000.01694.x). (PMID:10632875).

Compton, S.J., Cairns, J.A., Holgate, S.T. and Walls, A.F. (2000) Human mast cell tryptase stimulates the release of an IL-8-dependent neutrophil chemotactic activity from human umbilical vein endothelial cells (HUVEC). Clinical and Experimental Immunology, 121, (1), 31-36. (doi:10.1046/j.1365-2249.2000.01271.x).

Compton, Steven J., Cairns, Jennifer A., Palmer, Karan-Jane, AL-Ani, Bahjat, Hollenberg, Morley D. and Walls, Andrew F. (2000) A polymorphic protease activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. Journal of Biological Chemistry, 275, 39207-39212. (doi:10.1074/jbc.M007215200). (PMID:10995771).

Cox, Barnaby, Hadjantonakis, Anna-Katerina, Collins, Jane E. and Magee, Anthony I. (2000) Cloning and expression throughout mouse development of mfat, a homologue of the Drosophila tumour suppressor gene fat. Developmental Dynamics, 217, (3), 233-240. (doi:10.1002/(ISSN)1097-0177).

Faust, S.N . and Levin, M. (2000) Managing abnormal clotting in intensive care. Current Paediatrics, 10, (1), 5-13. (doi:10.1054/cupe.1999.0069 ).

Faust, S.N., Heyderman, R.S., Harrison, O., Goldin, R.D., Laszik, Z., Esmon, C.T. and Levin, M. (2000) Molecular mechanisms of thrombosis in meningococcal septicaemia: the role of the protein C pathway in vivo. Shock, 13, (Supplement 1), p.29.

Faust, S.N., Heyderman, R.S. and Levin, M. (2000) Disseminated intravascular coagulation and purpura fulminans secondary to infection. Best Practice & Research Clinical Haematology, 13, (2), 179-197. (doi:10.1053/beha.2000.0067). (PMID:10942620).

Fleming, J.S., Sauret, V., Conway, J.H., Holgate, S.T., Bailey, A.G. and Martonen, T.B. (2000) Evaluation of the accuracy and precision of lung aerosol deposition measurements from single-photon emission computed tomography using simulation. Journal of Aerosol Medicine, 13, (3), 187-198.

Gadola, S.D., Moins-Teisserenc , H.T., Trowsdale, J., Gross, W.L. and Cerundola, V. (2000) TAP deficiency syndrome. Clinical and Experimental Immunology, 121, (2), 173-178. (doi:10.1046/j.1365-2249.2000.01264.x).

Hardy, Samantha J., Christodoulides, Myron, Weller, Roy O. and Heckels, John E. (2000) Interactions of Neisseria meningitidis with cells of the human meninges. Molecular Microbiology, 36, (4), 817-829. (doi:10.1046/j.1365-2958.2000.01923.x). (PMID:10844670).

Heuschkel, R.B., MacDonald, T.T., Monteleone, G., Bajaj-Elliott, M., Smith, J.A. and Pender, S.L. (2000) Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease. Gut, 47, (1), 57-62. (doi:10.1136/gut.47.1.57).

Holgate, S.T. (2000) The bronchial epithelial origins of asthma. Chemical Immunology, 78, 62-71. (doi;10.1159/000058817).

Holgate, S.T. (2000) Epithelial damage and response. Clinical and Experimental Allergy, 30, (supplement 1), 37-41.

Holgate, S.T. (2000) Inflammatory and structural changes in the airways of patients with asthma. Respiratory Medicine, 94, (Supplement 4), S3-S6. (doi:10.1016/S0954-6111(00)80133-X).

Holgate, S.T. (2000) The role of mast cells and basophils in inflammation. Clinical and Experimental Allergy, 30, (supplement 1), 28-32.

Holgate, Stephen T., Davies, Donna E., Lackie, Peter M., Wilson, Susan J., Puddicombe, Sarah M. and Lordan, James L. (2000) Epithelial-mesenchymal interactions in the pathogenesis of asthma. The Journal of Allergy and Clinical Immunology, 105, (2), part 1, 193-204. (doi:10.1016/S0091-6749(00)90066-6 ). (PMID:10669837).

Holgate, Stephen T., Lackie, Peter, Wilson, Susan, Roche, William and Davies, Donna (2000) Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma. American Journal of Respiratory and Critical Care Medicine, 162, (3), S113-S117.

Holloway, J., Dunbar, P., Riley, G., Sawyer, G., Fitzharris, P., Pearce, N., Le Gros, G. and Beasley, R. (2000) Association of beta2-adrenergic receptor polymorphisms with severe asthma. Clinical & Experimental Allergy, 30, (8), 1097-103. (doi:10.1046/j.1365-2222.2000.00929.x). (PMID:10931116).

Jesenik, Friedrich, Springall, David R., Redington, Anthony E., Doré, Caroline J., Abrams, Don-Carlos, Holgate, Stephen T., Howarth, Peter H. and Polak, Julia M. (2000) Validation of endobronchial biopsy specimens for nerve quantitation by computer-assisted image analysis. Journal of Pathology, 192, (4), 545-548. (doi:10.1002/1096-9896(200012)192:4<545::AID-PATH755>3.0.CO;2-V).

Jones, Graeme R., Williams, Jeanette N., Christodoulides, Myron, Jolley, Keith and Heckels, John E. (2000) Lack of immunity in university students before an outbreak of serogroup C meningococcal infection. Journal of Infectious Diseases, 181, (3), 1172-1175. (doi:10.1086/315352). (PMID:10720549).

Leckie, Margaret J., ten Brinke, Anneke, Khan, Jamey, Diamant, Zuzana, O'Connor, Brian J., Walls, Christine M., Mathur, Ashwini K., Cowley, Hugh C., Chung, K. Fan, Djukanovic, Ratko, Hansel, Trevor T., Holgate, Stephen T., Sterk, Peter J. and Barnes, Peter J. (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet, 356, (9248), 2144-2148. ( doi:10.1016/S0140-6736(00)03496-6).

Levin, Michael , Quint, Peter A., Goldstein, Brahm , Barton, Phil , Bradley, John S., Shemie, S.D. , Yeh, Timothy , Kim , Sun Sook , Cafaro, Daniel P., Scanno, Patrick J., Giroir, Brett P., Faust, Saul N. and rBPI21 Meningococcal Sepsis Study Group (2000) Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. The Lancet, 356, (9234), 961-967. (doi:10.1016/S0140-6736(00)02712-4 ).

Lewith, George and Holgate, Stephen (2000) CAM research and development. Complementary Therapies in Nursing & Midwifery, 6, (1), 19-24. (doi:10.1054/ctnm.1999.0440).

Linaker, Catherine H., Chauhan, Anoop J., Inskip, Hazel M., Holgate, Stephen T. and Coggon, David (2000) Personal exposures of children to nitrogen dioxide relative to concentrations in outdoor air. Occupational and Environmental Medicine, 57, (7), 472-476.

Liu, B.L., Everson, J., Fane, B., Giannikopoulou, P., Vretou, E., Lambden, P.R. and Clarke, I.N. (2000) Molecular characterization of a bacteriophage (Chp2) from chlamydia psittaci. Journal of Virology, 74, (8), 3464-3469. (PMID:8375644).

Lonjou, C., Barnes, K., Chen, H., Cookson, W.O., Deichmann, K.A., Hall, I.P., Holloway, J.W., Laitinen, T., Palmer, L.J., Wjst, M. and Morton, N.E. (2000) A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG). Proceedings of the National Academy of Sciences of the United States of America, 97, (20), 10942-10947. (doi:10.1073/pnas.97.20.10942). (PMID:10369254).

Lucas, J.S., Foreman, C.T. and Clough, J.B. (2000) Measuring lung function in infancy. Respiratory Medicine, 94, (7), 641-647. (doi:10.1053/rmed.2000.0792). (PMID:10926334).

MacDonald, T.T., Monteleone, G. and Pender, S.L. (2000) Recent developments in the immunology of inflammatory bowel disease. Scandinavian Journal of Immunology, 51, (1), 2-9. (doi:10.1046/j.1365-3083.2000.00658.x).

Monteleone, G., Pender, S.L.F. and MacDonald, T.T. (2000) Modulation of Th1 responses, tissue injury and matrix metalloproteinases in human gut. In, Corazza, Gina Roberto and Tinozzi, Stephano (eds.) Attualita sul morbo di Crohn. , Cisalpino, 45.

Nagata, Satoru, McKenzie, Catriona, Pender, Sylvia L.F., Bajaj-Elliott, Mona, Fairclough, Peter D., Walker-Smith, John A., Monteleone, Giovanni and MacDonald, Thomas T. (2000) Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. Journal of Immunology, 165, (9), 5315-5321.

Pender, S.L., Salmela, M.T., Monteleone, G., Schnapp, D., McKenzie, C., Spencer, J., Fong, S., Saarialho-Kere, U. and MacDonald, T.T. (2000) Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype. The American Journal of Pathology, 157, (6), 1955-1962.

Pender, Sylvia L.F., Quinn, Jessica J., Sanderson, Ian R. and MacDonald, Thomas T. (2000) Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. American Journal of Physiology. Gastrointestinal and Liver Physiology, 279, (5), G918-G924.

Pillai, C., Dua, H.S. and Hossain, P. (2000) Fine needle diathermy occlusion of corneal vessels. Investigative Ophthalmology & Visual Science, 41, (8), 2148-2153. (PMID:10892856).

Polosa, Riccardo, Prosperini, Gaetano, Tomaselli, Valerio, Howarth, Peter H., Holgate, Stephen T. and Davies, Donna E. (2000) Expression of c-erbB receptors and ligands in human nasal epithelium. Journal of Allergy and Clinical Immunology, 106, (6), 1124-1131. (doi:10.1067/mai.2000.110931).

Puddicombe, S.M., Polosa, R., Richter, A., Krishna, M.T., Howarth, P.H., Holgate, S.T. and Davies, D.E. (2000) Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB Journal, 14, (10), 1362-1374.

Redington, Anthony E., Wilson, John W., Walls, Andrew F., Madden, Jacqueline, Djukanovic, Ratko, Holgate, Stephen T. and Howarth, Peter H. (2000) Persistent airway T-lymphocyte activation in chronic corticosteroid-treated symptomatic asthma. Annals of Allergy, Asthma & Immunology, 85, (6), 501-507.

Salvi, S.S., Babu, K.S. and Holgate, S.T. (2000) Glucocorticoids enhance IgE synthesis. Are we heading towards new paradigms. Clinical and Experimental Allergy, 30, (11), 1499-1505. (doi:10.1046/j.1365-2222.2000.00990.x).

Salvi, Sundeep S., Nordenhall, Charlotta, Blomberg, Anders, Rudell, Bertil, Pourazar, Jamshid, Kelly, Frank J., Wilson, Susan J., Sandström, Thomas, Holgate, Stephen T. and Frew, Anthony J. (2000) Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. American Journal of Respiratory and Critical Care Medicine, 161, (2 ), part 1, 550-557. (PMID:10673199).

Sampson, A.P., Siddiqui, S., Buchanan, D., Howarth, P.H., Holgate, S.T., Holloway, J.W. and Sayers, I. (2000) Variant LTC4 synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast. Thorax, 55, (Suppl 2), S28-S31.

Stevens, C.R., Millar, T.M., Clinch , J.G., Kanczler, J.M., Bodamyali, T and Blake, D.R. (2000) Antibacterial properties of xanthine oxidase in human milk. Lancet, 356, (9232), 829-830. (doi:10.1016/S0140-6736(00)02660-X). (PMID:11022933).

Thomas, N. Simon, Wilkinson, Jane, Lonjou, Christine, Morton, Newton E. and Holgate, Stephen T. (2000) Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population. American Journal of Respiratory and Critical Care Medicine, 162, (4), 1268-1272.

Thomas, N.S., Wilkinson, J., Lio, P., Doull, I., Morton, N.E. and Holgate, S.T. (2000) [Genetic factors involved in asthma and atopy. Studies in British families]. Revue des Maladies Respiratoires, 17, (1 Pt 2), 177-182.

Tomasec, Peter, Braud, Veronique M., Rickards, Carole, Powell, Martin B., McSharry, Brain P., Gadola, Stephan, Cerundolo, Vincenzo, Borysiewicz, Leszek K., McMichael, Andrew J. and Wilkinson, Gavin W.G. (2000) Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science, 287, (5455), 1031-1033. (doi:10.1126/science.287.5455.1031). (PMID:10669413).

Vipond, I. Barry, Pelosi, Emmanuela, Williams, Judith, Ashley, Charles R., Lambden, Paul R., Clarke, Ian N. and Caul, E. Owen (2000) A diagnostic EIA for detection of the prevalent SRSV strain in United Kingdom outbreaks of gastroenteritis. Journal of Medical Virology, 61, (1), 132-137. (doi:10.1002/(SICI)1096-9071(200005)61:1<132::AID-JMV21>3.0.CO;2-8). (PMID:10745245).

Vrugt, B, Wilson, Susan J., Bron, A, Shute, J, Holgate, Stephen T., Djukanovic, Ratko and Aalbers, R (2000) Low-dose methotrexate treatment in severe glucocorticoid-dependent asthma: effect on mucosal inflammation and in vitro sensitivity to glucocorticoids of mitogen-induced T-cell proliferation. European Respiratory Journal, 15, (3), 478-485. (PMID:10759440).

Vrugt, B., Wilson, S., Bron, A., Holgate, S.T., Djukanovic, R. and Aalbers, R. (2000) Bronchial angiogenesis in severe glucocorticoid-dependent asthma. European Respiratory Journal, 15, (6), 1014-1021.

Warner, Jill A. and Warner, John O. (2000) Early life events in allergic sensitisation. British Medical Bulletin, 56, (4), 883-893.

Williams, Elizabeth J., Hague, Seleena, Banks, Charmain, Johnson, Penny, Sarsfield, Patrick and Sheron, Nick (2000) Distribution of the interleukin-8 receptors, CXCR1 and CXCR2 in inflamed gut tissue. The Journal of Pathology, 192, (4), 533-539. (doi:10.1002/1096-9896(2000)9999:9999<::AID-PATH732>3.0.CO;2-X).

Wilson, S.J., Shute, J.K., Holgate, S.T., Howarth, P.H. and Bradding, P. (2000) Localization of interleukin (IL) -4 but not IL-5 to human mast cell secretory granules by immunoelectron microscopy. Clinical and Experimental Allergy, 30, (4), 493-500. (doi:10.1046/j.1365-2222.2000.00756.x). (PMID:10718846).

Withers, N.J., Low, J.L., Holgate, S.T. and Clough, J.B. (2000) Smoking habits in a cohort of U.K. adolescents. Respiratory Medicine, 94, (4), 391-396. (doi:10.1053/rmed.1999.0746).

Wright, Sarah M., Hockey, Peter M., Enhorning, Goran, Strong, Peter, Reid, Kenneth B., Holgate, Stephen T., Djukanovic, Ratko and Postle, Anthony D. (2000) Altered airway surfactant phospholipid composition and reduced lung function in asthma. Journal of Applied Physiology, 89, (4), 1283-1292.