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The cooling effect of liquid flow on the focussed ultrasound-induced heating in a simulated foetal brain

The cooling effect of liquid flow on the focussed ultrasound-induced heating in a simulated foetal brain
The cooling effect of liquid flow on the focussed ultrasound-induced heating in a simulated foetal brain
There is a need to investigate the thermal effects of diagnostic ultrasound (US) to assist the development of appropriate safety guidelines for obstetric use. The cooling effect of a single liquid flow channel was measured in a model of human foetal brain and skull bone heated by a focussed beam of simulated pulsed spectral Doppler US. Insonation conditions were 5.7 s pulses, repeated at 8 kHz from a focussed transducer operating with a centre frequency of 3.5 MHz, producing a beam of ?6 dB diameter of 3.1 mm at the focus and power outputs of up to 255 ± 5 mW. Brain perfusion was simulated by allowing distilled water to flow at various rates in a 2 mm diameter wall-less channel in the brain soft tissue phantom material. This study established that the cooling effect of the flowing water; 1. was independent of the acoustic source power, 2. was more effective close to the flow channel, for example, there was a marked cooling at a distance of 1 mm and negligible cooling at a distance of 3 mm from the channel; and 3. initially increased at low flow rates, but further increase above normal perfusion had very little effect.
pulsed ultrasound, phantom, foetus, liquid flow, bone heating, hyperthermia, focussed ultrasound beam
0301-5629
1193-1204
Vella, G.J.
831f4545-9172-482d-a838-e9145773dae2
Humphrey, V.F.
23c9bd0c-7870-428f-b0dd-5ff158d22590
Duck, F.A.
a1178433-533c-4547-8710-3413f044a119
Barnett, S.B.
1e755f4b-00b6-4f9b-8e91-34fa27792ca0
Vella, G.J.
831f4545-9172-482d-a838-e9145773dae2
Humphrey, V.F.
23c9bd0c-7870-428f-b0dd-5ff158d22590
Duck, F.A.
a1178433-533c-4547-8710-3413f044a119
Barnett, S.B.
1e755f4b-00b6-4f9b-8e91-34fa27792ca0

Vella, G.J., Humphrey, V.F., Duck, F.A. and Barnett, S.B. (2003) The cooling effect of liquid flow on the focussed ultrasound-induced heating in a simulated foetal brain. Ultrasound in Medicine & Biology, 29 (8), 1193-1204. (doi:10.1016/S0301-5629(03)00064-4).

Record type: Article

Abstract

There is a need to investigate the thermal effects of diagnostic ultrasound (US) to assist the development of appropriate safety guidelines for obstetric use. The cooling effect of a single liquid flow channel was measured in a model of human foetal brain and skull bone heated by a focussed beam of simulated pulsed spectral Doppler US. Insonation conditions were 5.7 s pulses, repeated at 8 kHz from a focussed transducer operating with a centre frequency of 3.5 MHz, producing a beam of ?6 dB diameter of 3.1 mm at the focus and power outputs of up to 255 ± 5 mW. Brain perfusion was simulated by allowing distilled water to flow at various rates in a 2 mm diameter wall-less channel in the brain soft tissue phantom material. This study established that the cooling effect of the flowing water; 1. was independent of the acoustic source power, 2. was more effective close to the flow channel, for example, there was a marked cooling at a distance of 1 mm and negligible cooling at a distance of 3 mm from the channel; and 3. initially increased at low flow rates, but further increase above normal perfusion had very little effect.

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More information

Published date: 2003
Keywords: pulsed ultrasound, phantom, foetus, liquid flow, bone heating, hyperthermia, focussed ultrasound beam

Identifiers

Local EPrints ID: 10337
URI: http://eprints.soton.ac.uk/id/eprint/10337
ISSN: 0301-5629
PURE UUID: 49b4164c-cb2b-4816-bb0c-2065962669b5
ORCID for V.F. Humphrey: ORCID iD orcid.org/0000-0002-3580-5373

Catalogue record

Date deposited: 19 May 2005
Last modified: 16 Mar 2024 03:34

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Contributors

Author: G.J. Vella
Author: V.F. Humphrey ORCID iD
Author: F.A. Duck
Author: S.B. Barnett

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