Estimation of coherence between cerebral blood flow velocity and EEG activity in newborn babies

Simpson, D.M., Botero Rosas, D.A. and Infantosi, A.F.C. (2002) Estimation of coherence between cerebral blood flow velocity and EEG activity in newborn babies. Annual Scientific Meeting of the Institute of Physics and Engineering in Medicine, Durham, UK. 09 - 11 Sep 2002. pp. 58-59 .

Abstract

Introduction: Blood flow to the brain is normally regulated by control mechanisms, whose failure has been linked to cerebral ischaemia and intracranial haemorrhage. We have been investigating this control in neonates using transcranial Doppler measurements of cerebral blood flow velocity (CBFV), and have shown correlation between CBFV and the power of the EEG. The aim of the current work is to identify the frequency range in which the EEG activity is most strongly linked to CBFV, using coherence estimates.
Methods: CBFV and EEG were simultaneously recorded in normal neonates. In 12 recordings (from 9 neonates), the normal neonatal EEG pattern of Tracé Alternant was identified. Mean CBFV and the RMS value of the EEG were calculated in one-second intervals. The coherence between the resulting signals was estimated using an algorithm developed for signals with missing samples (excluding signal segments with noise or artefact), followed by Monte Carlo statistical tests of significance.
Results: It was found that coherence peaked at approximately 0.1 Hz, with a median value of the coherence-magnitude of 0.57. Coherence was significant in 8 of the 12 records. The RMS value of the EEG also showed a spectral peak at 0.1 Hz, but the mean CBFV generally did not.

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Contributors

Author: D.M. Simpson

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