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Domicilary chemotherapy with gemcitabine is safe and acceptable to advanced non-small cell lung cancer patients – results of a feasibility study

Domicilary chemotherapy with gemcitabine is safe and acceptable to advanced non-small cell lung cancer patients – results of a feasibility study
Domicilary chemotherapy with gemcitabine is safe and acceptable to advanced non-small cell lung cancer patients – results of a feasibility study
A study was conducted to investigate the feasibility and acceptability of administering single-agent gemcitabine to patients with advanced non-small-cell lung cancer (NSCLC) in their own homes. Gemcitabine is an active agent in NSCLC with a good toxicity profile and lends itself to this type of investigation. A total of 24 patients were studied; as only one patient required gemcitabine to be changed from home administration to hospital administration, domiciliary gemcitabine is feasible. A total of 249 injections of gemcitabine were given, the mean number of courses being 3.5, range 1-6. The gemcitabine was given at 1000 mg m-2 on days 1, 8 and 15, the courses being repeated every 28 days. All patients received their first course in hospital and in total 147 were given at home and only 14 in hospital on courses 2-6. Furthermore, both the patients and carers reported positively on the use of domiciliary gemcitabine and preferred it over hospital administration. There was no evidence of increasing burden to community services during the domiciliary chemotherapy. Further studies investigating this approach are warranted.
domiciliary chemotherapy, gemcitabine, lung cancer, advanced NSCLC
0007-0920
2190-2196
Anderson, H.
eeb72db9-1142-4ded-8565-4ed17821b9d0
Addington-Hall, J.M.
87560cc4-7562-4f9b-b908-81f3b603fdd8
Peake, M.D.
2856cc8e-b513-4837-84f7-dda5f268053d
McKendrick, J.
c485d931-6c98-4839-ada7-250ebd9175e6
Keane, K.
99b6d2fd-8701-4b19-9b8b-ff3129e7d9a8
Thatcher, N.
6c462e0e-6053-4fd9-80d0-9bccb6afb2ea
Anderson, H.
eeb72db9-1142-4ded-8565-4ed17821b9d0
Addington-Hall, J.M.
87560cc4-7562-4f9b-b908-81f3b603fdd8
Peake, M.D.
2856cc8e-b513-4837-84f7-dda5f268053d
McKendrick, J.
c485d931-6c98-4839-ada7-250ebd9175e6
Keane, K.
99b6d2fd-8701-4b19-9b8b-ff3129e7d9a8
Thatcher, N.
6c462e0e-6053-4fd9-80d0-9bccb6afb2ea

Anderson, H., Addington-Hall, J.M., Peake, M.D., McKendrick, J., Keane, K. and Thatcher, N. (2004) Domicilary chemotherapy with gemcitabine is safe and acceptable to advanced non-small cell lung cancer patients – results of a feasibility study. British Journal of Cancer, 89 (12), 2190-2196. (doi:10.1038/sj.bjc.6601420).

Record type: Article

Abstract

A study was conducted to investigate the feasibility and acceptability of administering single-agent gemcitabine to patients with advanced non-small-cell lung cancer (NSCLC) in their own homes. Gemcitabine is an active agent in NSCLC with a good toxicity profile and lends itself to this type of investigation. A total of 24 patients were studied; as only one patient required gemcitabine to be changed from home administration to hospital administration, domiciliary gemcitabine is feasible. A total of 249 injections of gemcitabine were given, the mean number of courses being 3.5, range 1-6. The gemcitabine was given at 1000 mg m-2 on days 1, 8 and 15, the courses being repeated every 28 days. All patients received their first course in hospital and in total 147 were given at home and only 14 in hospital on courses 2-6. Furthermore, both the patients and carers reported positively on the use of domiciliary gemcitabine and preferred it over hospital administration. There was no evidence of increasing burden to community services during the domiciliary chemotherapy. Further studies investigating this approach are warranted.

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More information

Published date: 2004
Keywords: domiciliary chemotherapy, gemcitabine, lung cancer, advanced NSCLC

Identifiers

Local EPrints ID: 11093
URI: http://eprints.soton.ac.uk/id/eprint/11093
ISSN: 0007-0920
PURE UUID: 783a2a32-4064-487c-ae9d-8ca196b3942c

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Date deposited: 27 Oct 2004
Last modified: 15 Jul 2019 19:36

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