Looking inside solid supports: Confocal Raman Microscopy of polymer beads
Looking inside solid supports: Confocal Raman Microscopy of polymer beads
We have used scanning confocal Raman spectroscopy to explore the distribution of reaction sites and reacted sites within a variety of functionalised polymer beads used as solid phase supports for combinatorial chemistry. The balance between reagent diffusion in to the bead material and the rate of the reaction with the polymer support produces different distributions of reacted material within the bead that depend on the nature of the bead material (polystyrene, TentaGel, porous glass) and solvents employed. Comparisons between the use and Raman and fluorescence mapping will be highlighted and the factors that limit the spatial resolution within the bead will be discussed as well as the optical issues that can lead to distortion of the maps. Applications of Raman mapping, at the other end of the discovery process, looking at the distributions of materials in pharmaceutical preparations will be covered and the possible role of polarisation information will be explored.
raman confocal combinatorial beads polymer lens
Frey, Jeremy G.
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Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
Kress, Juergen
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Rose, Abbe
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Stanford, Helen
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6 October 2004
Frey, Jeremy G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
Kress, Juergen
80d30f16-2992-4f05-a6a3-c53dd216677d
Rose, Abbe
d3586ef7-1296-47c9-a3a7-f5207cdbe0ae
Stanford, Helen
9c7b5873-7709-40c1-b993-442053177648
Frey, Jeremy G., Bradley, Mark, Kress, Juergen, Rose, Abbe and Stanford, Helen
(2004)
Looking inside solid supports: Confocal Raman Microscopy of polymer beads.
FACSS 2004 (Federation of Analytical Chemistry and Spectroscopy Societies), Portland Oregon USA.
03 - 07 Oct 2004.
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Abstract
We have used scanning confocal Raman spectroscopy to explore the distribution of reaction sites and reacted sites within a variety of functionalised polymer beads used as solid phase supports for combinatorial chemistry. The balance between reagent diffusion in to the bead material and the rate of the reaction with the polymer support produces different distributions of reacted material within the bead that depend on the nature of the bead material (polystyrene, TentaGel, porous glass) and solvents employed. Comparisons between the use and Raman and fluorescence mapping will be highlighted and the factors that limit the spatial resolution within the bead will be discussed as well as the optical issues that can lead to distortion of the maps. Applications of Raman mapping, at the other end of the discovery process, looking at the distributions of materials in pharmaceutical preparations will be covered and the possible role of polarisation information will be explored.
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Published date: 6 October 2004
Venue - Dates:
FACSS 2004 (Federation of Analytical Chemistry and Spectroscopy Societies), Portland Oregon USA, 2004-10-03 - 2004-10-07
Keywords:
raman confocal combinatorial beads polymer lens
Identifiers
Local EPrints ID: 11235
URI: http://eprints.soton.ac.uk/id/eprint/11235
PURE UUID: 997db61f-674f-4d34-a63f-ed78d6c4a37f
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Date deposited: 05 Nov 2004
Last modified: 16 Mar 2024 02:34
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Contributors
Author:
Mark Bradley
Author:
Juergen Kress
Author:
Abbe Rose
Author:
Helen Stanford
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