The University of Southampton
University of Southampton Institutional Repository

A quantitative evaluation of spurious results in the infrared spectroscopic measurement of CO2 isotope ratios

Mansfield, C.D. and Rutt, H.N. (2002) A quantitative evaluation of spurious results in the infrared spectroscopic measurement of CO2 isotope ratios Physics in Medicine and Biology, 47, (4), pp. 689-696. (doi:10.1088/0031-9155/47/4/310).

Record type: Article

Abstract

The possible generation of spurious results, arising from the application of infrared spectroscopic techniques to the measurement of carbon isotope ratios in breath, due to coincident absorption bands has been re-examined. An earlier investigation, which approached the problem qualitatively, fulfilled its aspirations in providing an unambiguous assurance that 13C16O2/12C16O2 ratios can be confidently measured for isotopic breath tests using instruments based on infrared absorption. Although this conclusion still stands, subsequent quantitative investigation has revealed an important exception that necessitates a strict adherence to sample collection protocol. The results show that concentrations and decay rates of the coincident breath trace compounds acetonitrile and carbon monoxide, found in the breath sample of a heavy smoker, can produce spurious results. Hence, findings from this investigation justify the concern that breath trace compounds present a risk to the accurate measurement of carbon isotope ratios in breath when using broadband, non-dispersive, ground state absorption infrared spectroscopy. It provides recommendations on the length of smoking abstention required to avoid generation of spurious results and also reaffirms, through quantitative argument, the validity of using infrared absorption spectroscopy to measure CO2 isotope ratios in breath.

Full text not available from this repository.

More information

Published date: 2002

Identifiers

Local EPrints ID: 13779
URI: http://eprints.soton.ac.uk/id/eprint/13779
PURE UUID: 7eea4fac-293a-4653-878d-888eee433183

Catalogue record

Date deposited: 08 Feb 2005
Last modified: 17 Jul 2017 17:00

Export record

Altmetrics

Contributors

Author: C.D. Mansfield
Author: H.N. Rutt

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×