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Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy

Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
Purpose: hypercholesterolemia is a critical problem in patients with carotid atherosclerosis. The adequacy of attention to lipid risk factors in patients with carotid stenosis awaiting carotid endarterectomy (CEA) has rarely been studied. We also assessed patient awareness of hypercholesterolemia and carotid plaque morphology.

Methods: a prospective study was conducted of 141 consecutive patients admitted electively for CEA. Each patient’s medical history was taken. Plasma cholesterol concentrations were determined. Plaque histology was scored according to American Heart Association criteria and their modification.

Results: of patients who were aware of their hypercholesterolemia and who were receiving treatment, 28.6% had total cholesterol levels ?5 mmol/L. Among those patients who had been told that they had no problem with hypercholesterolemia, 32.5% had plasma cholesterol concentrations ?5 mmol/L. Among those patients who had never had their plasma cholesterol measured, 48.4% had total cholesterol levels ?5 mmol/L. Patients in this last group tended to have more severe types of plaque pathology than those in other groups (12.9% plaque rupture).

Conclusions: hypercholesterolemia does not seem to be well managed in patients awaiting CEA.
cholesterol, carotid endarterectomy, hypercholesterolemia, atherosclerotic plaque
1259-1264
Rerkasem, Kittipan
8343c03b-cdcf-4fbe-85ab-de7bf3896ca2
Gallagher, Patrick J.
14c495ef-03bd-499e-8feb-b4d8fa4508cf
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Shearman, Clifford P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf
Rerkasem, Kittipan
8343c03b-cdcf-4fbe-85ab-de7bf3896ca2
Gallagher, Patrick J.
14c495ef-03bd-499e-8feb-b4d8fa4508cf
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Shearman, Clifford P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf

Rerkasem, Kittipan, Gallagher, Patrick J., Grimble, Robert F., Calder, Philip C. and Shearman, Clifford P. (2008) Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy. Vascular Health and Risk Management, 4 (6), 1259-1264. (doi:10.2147/VHRM.S3729). (PMID:19337539)

Record type: Article

Abstract

Purpose: hypercholesterolemia is a critical problem in patients with carotid atherosclerosis. The adequacy of attention to lipid risk factors in patients with carotid stenosis awaiting carotid endarterectomy (CEA) has rarely been studied. We also assessed patient awareness of hypercholesterolemia and carotid plaque morphology.

Methods: a prospective study was conducted of 141 consecutive patients admitted electively for CEA. Each patient’s medical history was taken. Plasma cholesterol concentrations were determined. Plaque histology was scored according to American Heart Association criteria and their modification.

Results: of patients who were aware of their hypercholesterolemia and who were receiving treatment, 28.6% had total cholesterol levels ?5 mmol/L. Among those patients who had been told that they had no problem with hypercholesterolemia, 32.5% had plasma cholesterol concentrations ?5 mmol/L. Among those patients who had never had their plasma cholesterol measured, 48.4% had total cholesterol levels ?5 mmol/L. Patients in this last group tended to have more severe types of plaque pathology than those in other groups (12.9% plaque rupture).

Conclusions: hypercholesterolemia does not seem to be well managed in patients awaiting CEA.

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More information

Published date: September 2008
Keywords: cholesterol, carotid endarterectomy, hypercholesterolemia, atherosclerotic plaque
Organisations: Faculty of Medicine, Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 141528
URI: http://eprints.soton.ac.uk/id/eprint/141528
PURE UUID: f336afbd-5c43-40d6-a340-a4402b8988b8
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 29 Mar 2010 11:38
Last modified: 11 Mar 2021 02:35

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