The University of Southampton
University of Southampton Institutional Repository

Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: putative mechanisms and novel approaches

Kolias, Angelos G., Sen, Jon and Belli, Antonio (2009) Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: putative mechanisms and novel approaches Journal of Neuroscience Research, 87, (1), pp. 1-11. (doi:10.1002/jnr.21823). (PMID:18709660).

Record type: Article

Abstract

Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorly understood. However, intensive research during the last 3 decades has identified certain mechanisms that possibly play a role in its development. Experimental data suggest that calcium-dependent and -independent vasoconstriction is taking place during vasospasm. It appears that the breakdown products of blood in the subarachnoid space are involved, through direct and/or indirect pathways, in the development of vasospasm after SAH. Free radicals reactions, an imbalance between vasoconstrictor and vasodilator substances (endothelium derived substances, e.g., nitric oxide, endothelin; arachidonic acid metabolites, e.g., prostaglandins, prostacyclin), inflammatory processes, an upheaval of neuronal mechanisms that regulate vascular tone, endothelial proliferation, and apoptosis have all been put forward as causative and/or pathogenic factors. Translational research in the field of vasospasm has traditionally aimed to identify agents/interventions in order to block the cascades initiated after SAH. The combination of novel approaches such as cerebral microdialysis, magnetic resonance spectroscopy, proteomics, and lipidomics could serve a dual purpose: elucidating the complex pathobiochemistry of vasospasm and providing clinicians with tools for early detection of this feared complication. The purpose of this Mini-Review is to provide an overview of the pathogenesis of cerebral vasospasm and of novel approaches used in basic and translational research.

Full text not available from this repository.

More information

e-pub ahead of print date: 15 August 2008
Published date: January 2009
Keywords: stroke, cerebral aneurysm, delayed ischaemic neurological deficit, vasoconstriction, smooth muscle contraction, microdialysis

Identifiers

Local EPrints ID: 142003
URI: http://eprints.soton.ac.uk/id/eprint/142003
ISSN: 0360-4012
PURE UUID: 4e83bb64-a54b-473f-b53d-4421509ef715

Catalogue record

Date deposited: 30 Mar 2010 11:30
Last modified: 18 Jul 2017 23:12

Export record

Altmetrics

Contributors

Author: Angelos G. Kolias
Author: Jon Sen
Author: Antonio Belli

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×