The University of Southampton
University of Southampton Institutional Repository

SELDI-TOF MS Proteomics in Breast Cancer

Zeidan, Bashar A., Cutress, Ramsey I., Hastie, Claire, Mirnezami, Alex H., Packham, Graham and Townsend, Paul A. (2009) SELDI-TOF MS Proteomics in Breast Cancer Clinical Proteomics, 5, (3-4), pp. 133-147. (doi:10.1007/s12014-009-9032-5).

Record type: Article


Background: Proteomic profiling is a rapidly developing technology that may enable early disease screening and diagnosis. Surface-enhanced laser desorption ionization–time of flight mass spectrometry (SELDI-TOF MS) has demonstrated promising results in screening and early detection of many diseases. In particular, it has emerged as a high-throughput tool for detection and differentiation of several cancer types. This review aims to appraise published data on the impact of SELDI-TOF MS in breast cancer.

Methods: A systematic literature search between 1965 and 2009 was conducted using the PubMed, EMBASE, and Cochrane Library databases. Studies covering different aspects of breast cancer proteomic profiling using SELDI-TOF MS technology were critically reviewed by researchers and specialists in the field.

Results: Fourteen key studies involving breast cancer biomarker discovery using SELDI-TOF MS proteomic profiling were identified. The studies differed in their inclusion and exclusion criteria, biologic samples, preparation protocols, arrays used, and analytical settings. Taken together, the numerous studies suggest that SELDI-TOF MS methodology may be used as a fast and robust approach to study the breast cancer proteome and enable the analysis of the correlations between proteomic expression patterns and breast cancer.

Conclusion: SELDI-TOF MS is a promising high-throughput technology with potential applications in breast cancer screening, detection, and prognostication. Further studies are needed to resolve current limitations and facilitate clinical utility.

Full text not available from this repository.

More information

Published date: 30 June 2009
Keywords: breast cancer, seldi, proteomics, biomarkers


Local EPrints ID: 142283
PURE UUID: d2282a86-8eca-41e6-9ca9-473190960bf5

Catalogue record

Date deposited: 31 Mar 2010 14:12
Last modified: 18 Jul 2017 23:12

Export record



Author: Bashar A. Zeidan
Author: Claire Hastie
Author: Graham Packham
Author: Paul A. Townsend

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.