The University of Southampton
University of Southampton Institutional Repository

Cervical lymph nodes are found in direct relationship with the internal carotid artery: Significance for the lymphatic drainage of the brain

Clapham, R., O'Sullivan, E., Weller, Roy and Carare, Roxana Octavia (2009) Cervical lymph nodes are found in direct relationship with the internal carotid artery: Significance for the lymphatic drainage of the brain Clinical Anatomy, 23, (1), pp. 43-47. (doi:10.1002/ca.20887). (PMID:19918869).

Record type: Article

Abstract

The brain has no conventional lymphatics, but solutes injected into it drain along artery walls and reach lymph nodes in the neck. This study seeks to identify cervical lymph nodes related to the human internal carotid artery (ICA) that could act as the first regional lymph nodes for the brain. Bilateral dissections were carried out on four embalmed human heads, from the level of the carotid bifurcation in the neck, to the base of the skull. Lymph nodes from every specimen were processed for histological examination. A total of 51 deep cervical lymph nodes were identified: 12 lymph nodes (confirmed by histological examination) were observed to be in direct relationship with the ICA. These lymph nodes were found within the carotid sheath and had average diameters of 13.5 × 4.8 mm. Solutes and interstitial fluid from the brain may drain along the walls of cerebral arteries and reach these lymph nodes. They may be sites of stimulation of immune responses against antigens from the brain.

PDF Proof.pdf - Version of Record
Restricted to Repository staff only
Download (338kB)

More information

Published date: 13 November 2009
Keywords: lymph nodes, carotid sheath, internal carotid artery, brain, immune responses, interstitial fluid, perivascular, A?
Organisations: Clinical Neurosciences

Identifiers

Local EPrints ID: 142315
URI: http://eprints.soton.ac.uk/id/eprint/142315
ISSN: 0897-3806
PURE UUID: 67ade3cf-a9e5-4e29-8391-e7629d4bdfd9

Catalogue record

Date deposited: 31 Mar 2010 14:25
Last modified: 18 Jul 2017 23:12

Export record

Altmetrics

Contributors

Author: R. Clapham
Author: E. O'Sullivan
Author: Roy Weller

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×