Biaryl polyamides as a new class of DNA quadruplex-binding ligands
Biaryl polyamides as a new class of DNA quadruplex-binding ligands
We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
4097-4099
Rahman, Khondaker M.
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Reszka, Anthony P.
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Gunaratnam, Mekala
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Haider, Shozeb M.
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Howard, Philip W.
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Fox, Keith R.
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Neidle, Stephen
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Thurston, David E.
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21 July 2009
Rahman, Khondaker M.
c0ea8316-5dd1-4388-a818-cef8455e4d50
Reszka, Anthony P.
609ecf8e-24d6-4617-a2a8-aedc7646a5db
Gunaratnam, Mekala
4f1caed2-9930-4a4b-9a9e-c057f2ad83cd
Haider, Shozeb M.
3b8689a3-8a62-493a-a2ae-9ff82b24c0f0
Howard, Philip W.
1c34a0cd-4c24-4bf1-8ce1-a13006b57ba2
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Neidle, Stephen
edf2d7ee-a257-4d4c-a3ea-b3c9c42b5ff3
Thurston, David E.
9e2a56ac-259f-4977-a087-9d97c9003fbb
Rahman, Khondaker M., Reszka, Anthony P., Gunaratnam, Mekala, Haider, Shozeb M., Howard, Philip W., Fox, Keith R., Neidle, Stephen and Thurston, David E.
(2009)
Biaryl polyamides as a new class of DNA quadruplex-binding ligands.
Chemical Communications, 27, .
(doi:10.1039/b902359c).
(PMID:19568645)
Abstract
We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
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e-pub ahead of print date: 5 June 2009
Published date: 21 July 2009
Identifiers
Local EPrints ID: 142583
URI: http://eprints.soton.ac.uk/id/eprint/142583
ISSN: 1359-7345
PURE UUID: faa04874-581f-4441-8142-2230e5cc8e54
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Date deposited: 01 Apr 2010 15:47
Last modified: 14 Mar 2024 02:33
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Contributors
Author:
Khondaker M. Rahman
Author:
Anthony P. Reszka
Author:
Mekala Gunaratnam
Author:
Shozeb M. Haider
Author:
Philip W. Howard
Author:
Stephen Neidle
Author:
David E. Thurston
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