mTORC1 signalling and mRNA translation
mTORC1 signalling and mRNA translation
Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli. mTORC1 signalling regulates several components of the protein synthetic machinery, including initiation and elongation factors, protein kinases which phosphorylate the ribosome and/or translation factors, and the translation of specific mRNAs. However, there are still important gaps in our understanding of the actions of mTORC1 and the relative contributions that different targets of mTORC1 make to the activation of protein synthesis remain to be established
elongation factor, initiation factor, mammalian target of rapamycin (mTOR), mRNA, protein kinase, protein synthesis
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Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
2009
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
Proud, Christopher G.
(2009)
mTORC1 signalling and mRNA translation.
Biochemical Society Transactions, 37 (1), .
(doi:10.1042/BST0370227).
Abstract
Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli. mTORC1 signalling regulates several components of the protein synthetic machinery, including initiation and elongation factors, protein kinases which phosphorylate the ribosome and/or translation factors, and the translation of specific mRNAs. However, there are still important gaps in our understanding of the actions of mTORC1 and the relative contributions that different targets of mTORC1 make to the activation of protein synthesis remain to be established
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Published date: 2009
Keywords:
elongation factor, initiation factor, mammalian target of rapamycin (mTOR), mRNA, protein kinase, protein synthesis
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Local EPrints ID: 142717
URI: http://eprints.soton.ac.uk/id/eprint/142717
ISSN: 0300-5127
PURE UUID: 7f597e95-e54d-4822-b901-70e9422fe5f7
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Date deposited: 01 Apr 2010 15:50
Last modified: 14 Mar 2024 00:40
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Author:
Christopher G. Proud
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