The University of Southampton
University of Southampton Institutional Repository

Synaptopathy: dysfunction of synaptic function?

Brose, Nils, O'Connor, Vincent and Skehel, Paul (2010) Synaptopathy: dysfunction of synaptic function? Biochemical Society Transactions, 38, (2), pp. 443-444. (doi:10.1042/BST0380443).

Record type: Article

Abstract

Synaptopathy is an increasingly popular term used to define key features of neurodegenerative and psychiatric disease. It implies that disruptions in synaptic structure and function are potentially the major determinant of such brain diseases. The Synaptopathies: Dysfunction of Synaptic Function Biochemical Society Focused Meeting brought together several invited speakers, supplemented with short communications from young scientists, who addressed this possibility. The talks spanned the full gamut of approaches that brought molecular, cellular, systems and whole-animal experimentation together to address how fundamental synaptic biology was increasingly informing on dysfunction in disease. The disease and models thereof discussed included Alzheimer's disease, prions, Huntington's disease, Parkinson's disease, schizophrenia and autism. The audience were asked to reflect on whether synaptopathy, although attractive and conceptually useful, provided a significant explanation as the cause of these major diseases. The breadth of the meeting reinforced the complexity of these brain diseases, supported the significance of synaptic dysfunction in disease, but left open the issue as to whether the prime cause of these disorders could be resolved as simple synaptic dysfunction. Thus, despite revealing a value of synaptopathy, further investigation will be required to reveal its balance in the cause and effect in each of the major brain diseases.

Full text not available from this repository.

More information

Published date: April 2010

Identifiers

Local EPrints ID: 143379
URI: http://eprints.soton.ac.uk/id/eprint/143379
ISSN: 0300-5127
PURE UUID: e7cd983e-2f52-4f6e-a082-d3fb01decf8c

Catalogue record

Date deposited: 12 Apr 2010 08:40
Last modified: 18 Jul 2017 23:09

Export record

Altmetrics

Contributors

Author: Nils Brose
Author: Paul Skehel

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×