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A review of FMRFamide- and RFamide-like peptides in metazoa

A review of FMRFamide- and RFamide-like peptides in metazoa
A review of FMRFamide- and RFamide-like peptides in metazoa
Neuropeptides are a diverse class of signalling molecules that are widely employed as neurotransmitters and neuromodulators in animals, both invertebrate and vertebrate. However, despite their fundamental importance to animal physiology and behaviour, they are much less well understood than the small molecule neurotransmitters. The neuropeptides are classified into families according to similarities in their peptide sequence; and on this basis, the FMRFamide and RFamide-like peptides, first discovered in molluscs, are an example of a family that is conserved throughout the animal phyla. In this review, the literature on these neuropeptides has been consolidated with a particular emphasis on allowing a comparison between data sets in phyla as diverse as coelenterates and mammals. The intention is that this focus on the structure and functional aspects of FMRFamide and RFamide-like neuropeptides will inform understanding of conserved principles and distinct properties of signalling across the animal phyla.
invertebrate, vertebrate, neuropeptides, FaRP, phyla, neuropeptide
1354-2516
111-153
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Papaioannou, Sylvana
f125366e-9363-49ac-ab2d-87377e82d09a
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Papaioannou, Sylvana
f125366e-9363-49ac-ab2d-87377e82d09a
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e

Walker, Robert J., Papaioannou, Sylvana and Holden-Dye, Lindy (2010) A review of FMRFamide- and RFamide-like peptides in metazoa. Invertebrate Neuroscience, 9 (3), 111-153. (doi:10.1007/s10158-010-0097-7). (PMID:20191373)

Record type: Article

Abstract

Neuropeptides are a diverse class of signalling molecules that are widely employed as neurotransmitters and neuromodulators in animals, both invertebrate and vertebrate. However, despite their fundamental importance to animal physiology and behaviour, they are much less well understood than the small molecule neurotransmitters. The neuropeptides are classified into families according to similarities in their peptide sequence; and on this basis, the FMRFamide and RFamide-like peptides, first discovered in molluscs, are an example of a family that is conserved throughout the animal phyla. In this review, the literature on these neuropeptides has been consolidated with a particular emphasis on allowing a comparison between data sets in phyla as diverse as coelenterates and mammals. The intention is that this focus on the structure and functional aspects of FMRFamide and RFamide-like neuropeptides will inform understanding of conserved principles and distinct properties of signalling across the animal phyla.

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More information

Published date: 26 February 2010
Keywords: invertebrate, vertebrate, neuropeptides, FaRP, phyla, neuropeptide

Identifiers

Local EPrints ID: 143847
URI: http://eprints.soton.ac.uk/id/eprint/143847
ISSN: 1354-2516
PURE UUID: dba16365-e418-4379-b70b-b6477a6e16cb
ORCID for Robert J. Walker: ORCID iD orcid.org/0000-0002-9031-7671
ORCID for Lindy Holden-Dye: ORCID iD orcid.org/0000-0002-9704-1217

Catalogue record

Date deposited: 13 Apr 2010 11:59
Last modified: 18 Feb 2021 17:37

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