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Spindle cell tumour with glandular elements: an unusual ileal neoplasm

Spindle cell tumour with glandular elements: an unusual ileal neoplasm
Spindle cell tumour with glandular elements: an unusual ileal neoplasm
This report describes a tumour in the ileum with clinical features initially suggestive of a gastrointestinal stromal tumour (GIST). Histopathological examination revealed a biphasic tumour in which the spindle cell component showed immunohistochemical evidence of smooth muscle differentiation but without the characteristic profile of a GIST.

A well-differentiated epithelial component was also present, comprising glandular structures with immunohistochemical features suggestive of Mullerian differentiation. Similar glandular differentiation has been described in uterine leiomyomas but not, to our knowledge, in tumours associated with the small bowel.

None of the characteristic mutations of GISTs were identified in this case. There were no overt features of malignancy but, because of the unusual nature of the case, we assessed the biological behaviour as uncertain.
0021-9746
555-557
Bateman, A. C.
4e97a5ca-662c-451d-bdb3-33f35420ceed
Holgate, K.
57143668-8f7b-4d54-9bbc-e2317ef1f268
Green, B.
b8e56ad0-cfdc-4f53-86d5-d7563d2d6bd1
Thway, K.
9d48408a-6309-46a6-9b53-729cc6e0edeb
Primrose, J.
d85f3b28-24c6-475f-955b-ec457a3f9185
Bateman, A. C.
4e97a5ca-662c-451d-bdb3-33f35420ceed
Holgate, K.
57143668-8f7b-4d54-9bbc-e2317ef1f268
Green, B.
b8e56ad0-cfdc-4f53-86d5-d7563d2d6bd1
Thway, K.
9d48408a-6309-46a6-9b53-729cc6e0edeb
Primrose, J.
d85f3b28-24c6-475f-955b-ec457a3f9185

Bateman, A. C., Holgate, K., Green, B., Thway, K. and Primrose, J. (2009) Spindle cell tumour with glandular elements: an unusual ileal neoplasm. Journal of Clinical Pathology, 62 (6), 555-557. (doi:10.1136/jcp.2008.063990).

Record type: Article

Abstract

This report describes a tumour in the ileum with clinical features initially suggestive of a gastrointestinal stromal tumour (GIST). Histopathological examination revealed a biphasic tumour in which the spindle cell component showed immunohistochemical evidence of smooth muscle differentiation but without the characteristic profile of a GIST.

A well-differentiated epithelial component was also present, comprising glandular structures with immunohistochemical features suggestive of Mullerian differentiation. Similar glandular differentiation has been described in uterine leiomyomas but not, to our knowledge, in tumours associated with the small bowel.

None of the characteristic mutations of GISTs were identified in this case. There were no overt features of malignancy but, because of the unusual nature of the case, we assessed the biological behaviour as uncertain.

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Published date: June 2009

Identifiers

Local EPrints ID: 144845
URI: http://eprints.soton.ac.uk/id/eprint/144845
ISSN: 0021-9746
PURE UUID: c64e680f-c36a-4420-a034-8634e97466d5
ORCID for J. Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 15 Apr 2010 10:31
Last modified: 14 Mar 2024 02:37

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Contributors

Author: A. C. Bateman
Author: K. Holgate
Author: B. Green
Author: K. Thway
Author: J. Primrose ORCID iD

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