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Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma

Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma
Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma
Background: hepatocellular carcinoma (HCC) has a high worldwide prevalence and mortality. While surgical resection and transplantation offers curative potential, donor availability and patient liver status and comorbidities may disallow either. Interventional radiological techniques such as radiofrequency ablation (RFA) may offer acceptable overall and disease-free survival rates.

Materials and Methods: sixty-eight cirrhotic patients matched for age, sex, tumor size, and Child–Pugh grade with small (1–5 cm) unifocal HCC were studied retrospectively to find determinants of overall and disease-free survival in those treated with surgical resection and RFA between 1991 and 2003.
Results Multivariate analysis using Cox proportional regression modeling showed that overall survival was related to tumor recurrence (p?=?0.010), tumor diameter (p?=?0.002), and treatment modality (p?=?0.014); overall p?=?0.008. Recurrence was independently related to the use of RFA over surgery (p?=?0.023) on multivariate analysis; overall p?=?0.034.

Conclusion: surgical resection offers longer disease-free survival and potentially longer overall survival than RFA in patients with small unifocal HCC.
hepatocellular carcinoma, radio frequency ablation, resection
1091-255X
1521-1526
Abu-Hilal, M.
384e1c60-8519-4eed-8e92-91775aad4c47
Primrose, J.N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Casaril, A.
5da630e8-9302-45b0-b768-c76d2c007037
McPhail, M.J.W.
9b40d980-f980-4682-8deb-b76879bb2fcb
Pearce, N.W.
6134a6e9-897c-4607-b17b-a32bdf7a43c3
Nicoli, N.
6f8980e7-f566-490d-b9dc-a1337e632400
Abu-Hilal, M.
384e1c60-8519-4eed-8e92-91775aad4c47
Primrose, J.N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Casaril, A.
5da630e8-9302-45b0-b768-c76d2c007037
McPhail, M.J.W.
9b40d980-f980-4682-8deb-b76879bb2fcb
Pearce, N.W.
6134a6e9-897c-4607-b17b-a32bdf7a43c3
Nicoli, N.
6f8980e7-f566-490d-b9dc-a1337e632400

Abu-Hilal, M., Primrose, J.N., Casaril, A., McPhail, M.J.W., Pearce, N.W. and Nicoli, N. (2008) Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma. Journal of Gastrointestinal Surgery, 12 (9), 1521-1526. (doi:10.1007/s11605-008-0553-4).

Record type: Article

Abstract

Background: hepatocellular carcinoma (HCC) has a high worldwide prevalence and mortality. While surgical resection and transplantation offers curative potential, donor availability and patient liver status and comorbidities may disallow either. Interventional radiological techniques such as radiofrequency ablation (RFA) may offer acceptable overall and disease-free survival rates.

Materials and Methods: sixty-eight cirrhotic patients matched for age, sex, tumor size, and Child–Pugh grade with small (1–5 cm) unifocal HCC were studied retrospectively to find determinants of overall and disease-free survival in those treated with surgical resection and RFA between 1991 and 2003.
Results Multivariate analysis using Cox proportional regression modeling showed that overall survival was related to tumor recurrence (p?=?0.010), tumor diameter (p?=?0.002), and treatment modality (p?=?0.014); overall p?=?0.008. Recurrence was independently related to the use of RFA over surgery (p?=?0.023) on multivariate analysis; overall p?=?0.034.

Conclusion: surgical resection offers longer disease-free survival and potentially longer overall survival than RFA in patients with small unifocal HCC.

Full text not available from this repository.

More information

Published date: September 2008
Keywords: hepatocellular carcinoma, radio frequency ablation, resection

Identifiers

Local EPrints ID: 144851
URI: https://eprints.soton.ac.uk/id/eprint/144851
ISSN: 1091-255X
PURE UUID: 8125cc5a-6afa-4b90-a24d-5820837dec92
ORCID for J.N. Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 15 Apr 2010 10:27
Last modified: 16 Jun 2018 00:36

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