Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome
Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome
Although to date these observations in the fetal guinea pig have not been substantiated in humans, they provide strong preliminary evidence that impaired accumulation of DHA into brain phospholipids may be one important mechanism in the pathogenesis of FAS. Furthermore, since increasing DHA availability to the mother, and presumably the fetus, appeared to produce a reduction in the severity of ethanol-induced neurological damage it is possible that maternal DHA supplementation may provide a therapeutic strategy in humans FAS. Alternatively, the prolonged period of postnatal brain development in the human may permit appropriate dietary DHA supplementation of the affected infants after delivery, which would potentially be a more practical clinical intervention.
0444509224
159-167
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
February 2002
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Burdge, Graham C. and Postle, Anthony D.
(2002)
Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome.
In,
Krebs, Joachim and Michalak, Marek
(eds.)
Brain Lipids and Disorders in Biological Psychiatry.
(New Comprehensive Biochemistry, 35)
Kidlington, GB.
Elsevier, .
(doi:10.1016/S0167-7306(02)35038-5).
Record type:
Book Section
Abstract
Although to date these observations in the fetal guinea pig have not been substantiated in humans, they provide strong preliminary evidence that impaired accumulation of DHA into brain phospholipids may be one important mechanism in the pathogenesis of FAS. Furthermore, since increasing DHA availability to the mother, and presumably the fetus, appeared to produce a reduction in the severity of ethanol-induced neurological damage it is possible that maternal DHA supplementation may provide a therapeutic strategy in humans FAS. Alternatively, the prolonged period of postnatal brain development in the human may permit appropriate dietary DHA supplementation of the affected infants after delivery, which would potentially be a more practical clinical intervention.
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Published date: February 2002
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Local EPrints ID: 144931
URI: http://eprints.soton.ac.uk/id/eprint/144931
ISBN: 0444509224
PURE UUID: 25522d68-09f6-40ed-831c-ebe13baf43b9
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Date deposited: 07 Jul 2010 15:24
Last modified: 14 Mar 2024 02:31
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Editor:
Joachim Krebs
Editor:
Marek Michalak
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