Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome


Burdge, Graham C. and Postle, Anthony D. (2002) Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome In, Krebs, Joachim and Michalak, Marek (eds.) Brain Lipids and Disorders in Biological Psychiatry. Kidlington, GB, Elsevier pp. 159-167. (New Comprehensive Biochemistry, 35). (doi:10.1016/S0167-7306(02)35038-5).

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Description/Abstract

Although to date these observations in the fetal guinea pig have not been substantiated in humans, they provide strong preliminary evidence that impaired accumulation of DHA into brain phospholipids may be one important mechanism in the pathogenesis of FAS. Furthermore, since increasing DHA availability to the mother, and presumably the fetus, appeared to produce a reduction in the severity of ethanol-induced neurological damage it is possible that maternal DHA supplementation may provide a therapeutic strategy in humans FAS. Alternatively, the prolonged period of postnatal brain development in the human may permit appropriate dietary DHA supplementation of the affected infants after delivery, which would potentially be a more practical clinical intervention.

Item Type: Book Section
Digital Object Identifier (DOI): doi:10.1016/S0167-7306(02)35038-5
ISBNs: 0444509224 (print)
9780444509222 (print)
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ePrint ID: 144931
Date :
Date Event
February 2002Published
Date Deposited: 07 Jul 2010 15:24
Last Modified: 18 Apr 2017 19:59
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/144931

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