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Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome

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Although to date these observations in the fetal guinea pig have not been substantiated in humans, they provide strong preliminary evidence that impaired accumulation of DHA into brain phospholipids may be one important mechanism in the pathogenesis of FAS. Furthermore, since increasing DHA availability to the mother, and presumably the fetus, appeared to produce a reduction in the severity of ethanol-induced neurological damage it is possible that maternal DHA supplementation may provide a therapeutic strategy in humans FAS. Alternatively, the prolonged period of postnatal brain development in the human may permit appropriate dietary DHA supplementation of the affected infants after delivery, which would potentially be a more practical clinical intervention.

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Citation

Burdge, Graham C. and Postle, Anthony D. (2002) Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome In, Krebs, Joachim and Michalak, Marek (eds.) Brain Lipids and Disorders in Biological Psychiatry. Kidlington, GB, Elsevier pp. 159-167. (New Comprehensive Biochemistry, 35). (doi:10.1016/S0167-7306(02)35038-5).

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Published date: February 2002

Identifiers

Local EPrints ID: 144931
URI: http://eprints.soton.ac.uk/id/eprint/144931
ISBN: 0444509224
PURE UUID: 25522d68-09f6-40ed-831c-ebe13baf43b9
ORCID for Graham C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967
ORCID for Anthony D. Postle: ORCID iD orcid.org/0000-0001-7361-0756

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Date deposited: 07 Jul 2010 15:24
Last modified: 18 Jul 2017 23:07

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