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A mathematical model for simultaneous spatio-temporal dynamics of calcium and inositol 1,4,5-trisphosphate in Madin–Darby canine kidney epithelial cells

A mathematical model for simultaneous spatio-temporal dynamics of calcium and inositol 1,4,5-trisphosphate in Madin–Darby canine kidney epithelial cells
A mathematical model for simultaneous spatio-temporal dynamics of calcium and inositol 1,4,5-trisphosphate in Madin–Darby canine kidney epithelial cells
The landmark paper by Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527–1530, 1999) presented experimental investigations to show that not only can calcium upregulate IP3, but that it can also have an inhibitory effect on IP3. In this paper, we present a preliminary model, which is consistent with these experiments. This model includes positive and negative feedback between calcium and IP3 and is able to reproduce more precisely the data presented in Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527–1530, 1999). In the second part of the paper, the intracellular and intercellular calcium movement in Madin–Darby canine kidney epithelial cells is investigated. With the aid of the model we are able to identify the aspects of IP3 and calcium signalling, which should be studied further experimentally before refining the model
0092-8240
2027-2051
Roose, T.
3581ab5b-71e1-4897-8d88-59f13f3bccfe
Chapman, S. J.
fbc067f2-e0fe-4392-b458-34adc54b5624
Maini, P. K.
65a54fd7-c25f-46f1-94c1-f8e5850af132
Roose, T.
3581ab5b-71e1-4897-8d88-59f13f3bccfe
Chapman, S. J.
fbc067f2-e0fe-4392-b458-34adc54b5624
Maini, P. K.
65a54fd7-c25f-46f1-94c1-f8e5850af132

Roose, T., Chapman, S. J. and Maini, P. K. (2006) A mathematical model for simultaneous spatio-temporal dynamics of calcium and inositol 1,4,5-trisphosphate in Madin–Darby canine kidney epithelial cells. Bulletin of Mathematical Biology, 68 (8), 2027-2051. (doi:10.1007/s11538-006-9064-1).

Record type: Article

Abstract

The landmark paper by Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527–1530, 1999) presented experimental investigations to show that not only can calcium upregulate IP3, but that it can also have an inhibitory effect on IP3. In this paper, we present a preliminary model, which is consistent with these experiments. This model includes positive and negative feedback between calcium and IP3 and is able to reproduce more precisely the data presented in Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527–1530, 1999). In the second part of the paper, the intracellular and intercellular calcium movement in Madin–Darby canine kidney epithelial cells is investigated. With the aid of the model we are able to identify the aspects of IP3 and calcium signalling, which should be studied further experimentally before refining the model

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Published date: November 2006

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Local EPrints ID: 145159
URI: http://eprints.soton.ac.uk/id/eprint/145159
ISSN: 0092-8240
PURE UUID: 0ebff852-d302-488e-aad8-db3224265d6a
ORCID for T. Roose: ORCID iD orcid.org/0000-0001-8710-1063

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Date deposited: 18 Jun 2010 10:49
Last modified: 09 Jan 2022 03:29

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Contributors

Author: T. Roose ORCID iD
Author: S. J. Chapman
Author: P. K. Maini

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