The University of Southampton
University of Southampton Institutional Repository

No socioeconomic inequalities in colorectal cancer survival within a randomised clinical trial

Nur, U., Rachet, B., Parmar, M.K.B., Sydes, M.R., Cooper, N., Lepage, C., Northover, J.M.A., James, R., Coleman, M.P. and Primrose, J.N. (2008) No socioeconomic inequalities in colorectal cancer survival within a randomised clinical trial British Journal of Cancer, 99, (11), pp. 1923-1928. (doi:10.1038/sj.bjc.6604743).

Record type: Article


There is strong evidence that colorectal cancer survival differs between socioeconomic groups. We analysed data on 2481 patients diagnosed during 1989–1997 and recruited to a randomised controlled clinical trial (AXIS, ISRCTN32414363) of chemotherapy and radiotherapy for colorectal cancer. Crude and relative survival at 1 and 5 years was estimated in five categories of socioeconomic deprivation. Multiple imputation was used to account for missing data on tumour stage. A multivariable fractional polynomial model was fitted to estimate the excess hazard of death in each deprivation category, adjusting for the confounding effects of age, stage, cancer site (colon, rectum) and sex, using generalised linear models. Relative survival in the trial patients was higher than in the general population of England and Wales. The socioeconomic gradient in survival was much smaller than that seen for colorectal cancer patients in the general population, both at 1 year ?3.2% (95% CI ?7.3 to 1.0%, P=0.14) and at 5 years ?1.7% (95% CI ?8.3 to 4.9%, P=0.61). Given equal treatment, colorectal cancer survival in England and Wales does not appear to depend on socioeconomic status, suggesting that the socioeconomic gradient in survival in the general population could well be due to health-care system factors.

Full text not available from this repository.

More information

Published date: 28 November 2008
Keywords: colorectal cancer, rectum cancer, cancer survival, deprivation, cancer registries


Local EPrints ID: 145215
ISSN: 0007-0920
PURE UUID: 8eaa4e4f-5928-48b7-aa94-e9f9df5e165d
ORCID for J.N. Primrose: ORCID iD

Catalogue record

Date deposited: 16 Apr 2010 11:55
Last modified: 18 Jul 2017 23:06

Export record



Author: U. Nur
Author: B. Rachet
Author: M.K.B. Parmar
Author: M.R. Sydes
Author: N. Cooper
Author: C. Lepage
Author: J.M.A. Northover
Author: R. James
Author: M.P. Coleman
Author: J.N. Primrose ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.