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Heat shock proteins: therapeutic drug targets for chronic neurodegeneration?

Record type: Article

Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (“proteinopathies”). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimer's- and Parkinson's disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.

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Citation

Sajjad, M. U., Samson, B. and Wyttenbach, A. (2010) Heat shock proteins: therapeutic drug targets for chronic neurodegeneration? Current Pharmaceutical Biotechnology, 11, (2), pp. 198-215. (doi:10.2174/138920110790909641).

More information

Published date: February 2010

Identifiers

Local EPrints ID: 145341
URI: http://eprints.soton.ac.uk/id/eprint/145341
ISSN: 1389-2010
PURE UUID: 386353ee-d386-4fe4-86c6-98fed91cce3a

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Date deposited: 19 Apr 2010 08:30
Last modified: 18 Jul 2017 23:06

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Contributors

Author: M. U. Sajjad
Author: B. Samson
Author: A. Wyttenbach

University divisions


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