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Heat shock proteins: therapeutic drug targets for chronic neurodegeneration?

Sajjad, M. U., Samson, B. and Wyttenbach, A. (2010) Heat shock proteins: therapeutic drug targets for chronic neurodegeneration? Current Pharmaceutical Biotechnology, 11, (2), pp. 198-215. (doi:10.2174/138920110790909641).

Record type: Article


Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (“proteinopathies”). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimer's- and Parkinson's disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.

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Published date: February 2010


Local EPrints ID: 145341
ISSN: 1389-2010
PURE UUID: 386353ee-d386-4fe4-86c6-98fed91cce3a

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Date deposited: 19 Apr 2010 08:30
Last modified: 18 Jul 2017 23:06

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Author: M. U. Sajjad
Author: B. Samson
Author: A. Wyttenbach

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