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Sustained reduction of hypertension by deep brain stimulation

Sustained reduction of hypertension by deep brain stimulation
Sustained reduction of hypertension by deep brain stimulation
Deep brain stimulators were implanted in the left periaqueductal gray matter (PAG) and sensory thalamus for right sided neuropathic facial pain refractory to other treatments in a man aged 58 years. PAG stimulation 8 months later acutely reduced systolic blood pressure by 25 mm Hg during revision surgery. One year post procedure, ambulatory blood pressure monitoring demonstrated significant and sustained reduction in blood pressure with PAG stimulation. Mean systolic blood pressure decreased by 12.6 mm Hg and diastolic by 11.0 mm Hg, alongside reductions in variability of heart rate and pulse pressure. This neurosurgical treatment may prove beneficial for medically refractory hypertension.
autonomic nervous system, blood pressure, deep brain stimulation, pain, ambulatory blood pressure monitoring, periaqueductal grey area, periaqueductal gray
0967-5868
124-127
Pereira, Erlick A.C.
57b9193e-1e10-4172-aad1-616ff0690cae
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Paterson, David J.
cd51301d-9cfe-42de-81e1-aac2bfe0d5fd
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0
Green, Alexander L.
099ecb5e-2d66-41f3-9d1b-dc723a9bb01f
Pereira, Erlick A.C.
57b9193e-1e10-4172-aad1-616ff0690cae
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Paterson, David J.
cd51301d-9cfe-42de-81e1-aac2bfe0d5fd
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0
Green, Alexander L.
099ecb5e-2d66-41f3-9d1b-dc723a9bb01f

Pereira, Erlick A.C., Wang, Shouyan, Paterson, David J., Stein, John F., Aziz, Tipu Z. and Green, Alexander L. (2010) Sustained reduction of hypertension by deep brain stimulation. Journal of Clinical Neuroscience, 17 (1), 124-127. (doi:10.1016/j.jocn.2009.02.041).

Record type: Article

Abstract

Deep brain stimulators were implanted in the left periaqueductal gray matter (PAG) and sensory thalamus for right sided neuropathic facial pain refractory to other treatments in a man aged 58 years. PAG stimulation 8 months later acutely reduced systolic blood pressure by 25 mm Hg during revision surgery. One year post procedure, ambulatory blood pressure monitoring demonstrated significant and sustained reduction in blood pressure with PAG stimulation. Mean systolic blood pressure decreased by 12.6 mm Hg and diastolic by 11.0 mm Hg, alongside reductions in variability of heart rate and pulse pressure. This neurosurgical treatment may prove beneficial for medically refractory hypertension.

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More information

Published date: January 2010
Keywords: autonomic nervous system, blood pressure, deep brain stimulation, pain, ambulatory blood pressure monitoring, periaqueductal grey area, periaqueductal gray
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 145517
URI: https://eprints.soton.ac.uk/id/eprint/145517
ISSN: 0967-5868
PURE UUID: fad4ab74-e1b9-4324-948b-844b64d0676a

Catalogue record

Date deposited: 19 Apr 2010 08:37
Last modified: 17 Jul 2019 00:06

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