The effect of reduction of propellant mass fraction on the injection profile of metered dose inhalers
The effect of reduction of propellant mass fraction on the injection profile of metered dose inhalers
In order to provide an improved understanding of the flow in pressurized-metered dose inhalers (pMDIs), especially monitoring the output temperature and mass flow rate to obtain maximum atomization efficiency from the available energy, a numerical model for a two phases, multi-component compressible flow in a pressurized-metered dose inhaler is presented and validated. It is suitable for testing with various formulations and different geometries for a range of pMDI devices. We validated the model against available data in the literature for a single component HFA 134a propellant, and then investigated the response of the model to other formulations containing non-volatile components. Further validation is obtained by an experiment using the dual beam method which acquired the actuation flow properties such as spray velocity and duration. The deviation of the numerical predictions for the peak exit velocity against the experimental results is 5.3% and that for effective spray duration 5.0%. From the numerical and experimental results, it is found that for the formulations with the mass fraction of HFA 134a > 80%, the effective spray duration of the pMDI is around 0.1 s. Furthermore the droplet peak exit velocity at the axial station x = 25 mm from the actuation nozzle decreases from 20 to 15 m/s with the reduction of the propellant (HFA 134a) from 95%. Formulations with the mass fraction of HFA 134a below 80% produce poor quality spray which is indicated from the unsteady peak exit velocity, changeable spray number density in each experimental test, and numerical simulations also confirmed the non-viability of this condition.
flash evaporation, multiphase, atomization, model
221-229
Ju, Dehao
152e0f9a-b36c-4acf-9a21-6be7dd0515f9
Shrimpton, John S.
9cf82d2e-2f00-4ddf-bd19-9aff443784af
Hearn, Alex
3f049947-40b7-4fa4-b6f1-28df4a68deb9
31 May 2010
Ju, Dehao
152e0f9a-b36c-4acf-9a21-6be7dd0515f9
Shrimpton, John S.
9cf82d2e-2f00-4ddf-bd19-9aff443784af
Hearn, Alex
3f049947-40b7-4fa4-b6f1-28df4a68deb9
Ju, Dehao, Shrimpton, John S. and Hearn, Alex
(2010)
The effect of reduction of propellant mass fraction on the injection profile of metered dose inhalers.
International Journal of Pharmaceutics, 391 (1-2), .
(doi:10.1016/j.ijpharm.2010.03.003).
Abstract
In order to provide an improved understanding of the flow in pressurized-metered dose inhalers (pMDIs), especially monitoring the output temperature and mass flow rate to obtain maximum atomization efficiency from the available energy, a numerical model for a two phases, multi-component compressible flow in a pressurized-metered dose inhaler is presented and validated. It is suitable for testing with various formulations and different geometries for a range of pMDI devices. We validated the model against available data in the literature for a single component HFA 134a propellant, and then investigated the response of the model to other formulations containing non-volatile components. Further validation is obtained by an experiment using the dual beam method which acquired the actuation flow properties such as spray velocity and duration. The deviation of the numerical predictions for the peak exit velocity against the experimental results is 5.3% and that for effective spray duration 5.0%. From the numerical and experimental results, it is found that for the formulations with the mass fraction of HFA 134a > 80%, the effective spray duration of the pMDI is around 0.1 s. Furthermore the droplet peak exit velocity at the axial station x = 25 mm from the actuation nozzle decreases from 20 to 15 m/s with the reduction of the propellant (HFA 134a) from 95%. Formulations with the mass fraction of HFA 134a below 80% produce poor quality spray which is indicated from the unsteady peak exit velocity, changeable spray number density in each experimental test, and numerical simulations also confirmed the non-viability of this condition.
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Accepted/In Press date: 2010
Published date: 31 May 2010
Keywords:
flash evaporation, multiphase, atomization, model
Organisations:
Thermofluids and Superconductivity
Identifiers
Local EPrints ID: 145677
URI: http://eprints.soton.ac.uk/id/eprint/145677
ISSN: 0378-5173
PURE UUID: 00bf1748-72e0-44dc-86e0-e9d9d2eb1f93
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Date deposited: 19 Apr 2010 13:07
Last modified: 14 Mar 2024 00:51
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Author:
Dehao Ju
Author:
Alex Hearn
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