The University of Southampton
University of Southampton Institutional Repository

Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano

Herrera, Emilio A., Reyes, Roberto V., Giussani, Dino A., Riquelme, Raquel A., Sanhueza, Emilia M., Ebensperger, German, Casnello, Paola, Mendez, Natalia, Ebensperger, Renato, Sepulveda-Kattan, Esteban, Pulgar, Victor M., Cabello, Gertrudis, Blanco, Carlos E., Hanson, Mark A., Parer, Julian T. and Llanos, Anibal J. (2008) Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano Cardiovascular Research, 77, (1), pp. 197-201. (doi:10.1093/cvr/cvm013).

Record type: Article

Abstract

Aims: to study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas.

Methods and results: we used neonatal sheep (Ovis aries) and llamas (Lama glama) whose gestation and delivery took place at low (580 m) or high (3600 m) altitude. In vivo, we measured the cardiopulmonary function basally and with a NO synthase (NOS) blockade and calculated the production of carbon monoxide by the lung. In vitro, we determined NOS and soluble guanylate cyclase (sGC) expression, NOS activity, and haemoxygenase (HO) expression in the lung. Pulmonary arterial pressure was elevated at high altitude in sheep but not in llamas. Sheep at high altitude relative to sea level had significantly greater total lung NOS activity and eNOS protein, but reduced sGC and HO expression and carbon monoxide production. In contrast, llamas showed no difference in NO function between altitudes, but a pronounced increase in pulmonary carbon monoxide production and HO expression at high altitude.

Conclusions: in the llama, enhanced pulmonary carbon monoxide, rather than NO, protects against pulmonary hypertension in the newborn period at high altitude. This shift in pulmonary dilator strategy from NO to carbon monoxide has not been previously described, and it may give insight into new treatments for excessive pulmonary vasoconstriction.

Full text not available from this repository.

More information

Published date: 2008
Keywords: hypoxia, anoxia, pulmonary circulation, endothelial function, nitric oxide, vasoconstriction, dilation

Identifiers

Local EPrints ID: 145711
URI: http://eprints.soton.ac.uk/id/eprint/145711
ISSN: 0008-6363
PURE UUID: dafaf595-1d92-4ef5-8452-d1f59c43c043

Catalogue record

Date deposited: 19 Apr 2010 13:07
Last modified: 18 Jul 2017 23:06

Export record

Altmetrics

Contributors

Author: Emilio A. Herrera
Author: Roberto V. Reyes
Author: Dino A. Giussani
Author: Raquel A. Riquelme
Author: Emilia M. Sanhueza
Author: German Ebensperger
Author: Paola Casnello
Author: Natalia Mendez
Author: Renato Ebensperger
Author: Esteban Sepulveda-Kattan
Author: Victor M. Pulgar
Author: Gertrudis Cabello
Author: Carlos E. Blanco
Author: Mark A. Hanson
Author: Julian T. Parer
Author: Anibal J. Llanos

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×