Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent
Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent
The nutritional environment during development and even prior to conception may contribute to cardiovascular risk. In mature adult female sheep, we investigated the effect of preconceptional and periconceptional maternal nutritional restriction on the vascular reactivity of arteries from four vascular beds supplying the heart, thorax, kidney and hindlimb. Welsh Mountain ewes received 100% of nutrient requirements throughout gestation (control group, C, n = 18), or 50% of nutrient requirements for 30 days prior to conception (preconceptional group, PRE, n = 20) or for 15 days either side of conception (periconceptional group, PERI, n = 31) and 100% thereafter. In 3.5-year-old female offspring, the left anterior descending coronary (LAD), left internal thoracic (LITA), right renal and second and third order femoral arteries were dissected and their reactivity was assessed by organ bath or wire myography. Vasoconstrictor responses were greater in both LAD and LITA from PERI offspring compared with C (P < 0.01), while vasoconstriction was unaffected by maternal diet in arteries from the renal and femoral circulations (P = n.s.). Endothelium-dependent and -independent vasodilatation was attenuated in third order femoral arteries of PRE and PERI groups compared with C (P < 0.05). Endothelium-independent vasodilatation was attenuated in both the LAD and renal arteries in the PERI group compared with C (P < 0.05). These data show that moderate maternal undernutrition either prior to or around conception affects vascular function of adult offspring. The effect depends on the timing of the insult, but also on the vascular bed studied and vessel hierarchy in the vascular tree
1024-1033
Torrens, Christopher
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Snelling, Tristram H.
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Chau, Ryan
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Shanmuganathan, Meena
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Cleal, Jane K.
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Poore, Kirsten R.
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Noakes, David E.
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Poston, Lucilla
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Hanson, Mark A.
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Green, Lucy R.
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1 September 2009
Torrens, Christopher
15a35713-0651-4249-8227-5901e2cfcd22
Snelling, Tristram H.
127d082e-ee1b-404e-ab9d-490e299ccabe
Chau, Ryan
7197f680-6698-4384-91db-43bffb25b0a2
Shanmuganathan, Meena
bc2eb1e9-1aa5-4551-a1c2-de4e2417916c
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Poore, Kirsten R.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Noakes, David E.
d7f0b55e-8a82-4285-9b75-85f5aec6db8c
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, Lucy R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Torrens, Christopher, Snelling, Tristram H., Chau, Ryan, Shanmuganathan, Meena, Cleal, Jane K., Poore, Kirsten R., Noakes, David E., Poston, Lucilla, Hanson, Mark A. and Green, Lucy R.
(2009)
Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent.
Experimental Physiology, 94 (9), .
(doi:10.1113/expphysiol.2009.047340).
Abstract
The nutritional environment during development and even prior to conception may contribute to cardiovascular risk. In mature adult female sheep, we investigated the effect of preconceptional and periconceptional maternal nutritional restriction on the vascular reactivity of arteries from four vascular beds supplying the heart, thorax, kidney and hindlimb. Welsh Mountain ewes received 100% of nutrient requirements throughout gestation (control group, C, n = 18), or 50% of nutrient requirements for 30 days prior to conception (preconceptional group, PRE, n = 20) or for 15 days either side of conception (periconceptional group, PERI, n = 31) and 100% thereafter. In 3.5-year-old female offspring, the left anterior descending coronary (LAD), left internal thoracic (LITA), right renal and second and third order femoral arteries were dissected and their reactivity was assessed by organ bath or wire myography. Vasoconstrictor responses were greater in both LAD and LITA from PERI offspring compared with C (P < 0.01), while vasoconstriction was unaffected by maternal diet in arteries from the renal and femoral circulations (P = n.s.). Endothelium-dependent and -independent vasodilatation was attenuated in third order femoral arteries of PRE and PERI groups compared with C (P < 0.05). Endothelium-independent vasodilatation was attenuated in both the LAD and renal arteries in the PERI group compared with C (P < 0.05). These data show that moderate maternal undernutrition either prior to or around conception affects vascular function of adult offspring. The effect depends on the timing of the insult, but also on the vascular bed studied and vessel hierarchy in the vascular tree
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Published date: 1 September 2009
Organisations:
Dev Origins of Health & Disease
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Local EPrints ID: 145735
URI: http://eprints.soton.ac.uk/id/eprint/145735
ISSN: 0958-0670
PURE UUID: d58879c7-9197-4a68-8fba-896f0466b0e4
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Date deposited: 20 Apr 2010 07:52
Last modified: 14 Mar 2024 02:47
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Author:
Christopher Torrens
Author:
Tristram H. Snelling
Author:
Ryan Chau
Author:
Meena Shanmuganathan
Author:
David E. Noakes
Author:
Lucilla Poston
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