Supramolecular helical porphyrin arrays using DNA as a scaffold
Supramolecular helical porphyrin arrays using DNA as a scaffold
A diphenyl porphyrin substituted nucleotide was incorporated site specifically into DNA, leading to helical stacked porphyrin arrays in the major groove of the duplexes. The porphyrins show an electronic interaction which is significantly enhanced compared to the analogous tetraphenyl porphyrin (TPP) as shown in the large exciton coupling of the porphyrin B-band absorbance. Analogous to the TPP-DNA, an induced helical secondary structure is observed in the single strand porphyrin-DNA. The modified DNA can be hybridised to an immobilised complementary strand leading to fluorescent beads.
3888-3891
Bouamaied, Imenne
9938a8f5-740f-4c9c-9285-8a16a43a5fe5
Nguyen, ThaoNguyen
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Ruhl, Thomas
6cb8b8b2-e4b0-43d9-9ba0-5ef730c6c750
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
7 November 2008
Bouamaied, Imenne
9938a8f5-740f-4c9c-9285-8a16a43a5fe5
Nguyen, ThaoNguyen
b283dfdc-1b31-4bf8-a3d8-da4045479920
Ruhl, Thomas
6cb8b8b2-e4b0-43d9-9ba0-5ef730c6c750
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Bouamaied, Imenne, Nguyen, ThaoNguyen, Ruhl, Thomas and Stulz, Eugen
(2008)
Supramolecular helical porphyrin arrays using DNA as a scaffold.
Organic & Biomolecular Chemistry, 6 (21), .
(doi:10.1039/b813584c).
Abstract
A diphenyl porphyrin substituted nucleotide was incorporated site specifically into DNA, leading to helical stacked porphyrin arrays in the major groove of the duplexes. The porphyrins show an electronic interaction which is significantly enhanced compared to the analogous tetraphenyl porphyrin (TPP) as shown in the large exciton coupling of the porphyrin B-band absorbance. Analogous to the TPP-DNA, an induced helical secondary structure is observed in the single strand porphyrin-DNA. The modified DNA can be hybridised to an immobilised complementary strand leading to fluorescent beads.
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e-pub ahead of print date: 22 September 2008
Published date: 7 November 2008
Organisations:
Chemistry, Faculty of Natural and Environmental Sciences, Centre for Innovation & Enterprise
Identifiers
Local EPrints ID: 145789
URI: http://eprints.soton.ac.uk/id/eprint/145789
ISSN: 1477-0520
PURE UUID: 6d5d5294-054e-41d2-a892-aaf734ef3085
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Date deposited: 20 Apr 2010 08:23
Last modified: 14 Mar 2024 02:51
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Contributors
Author:
Imenne Bouamaied
Author:
ThaoNguyen Nguyen
Author:
Thomas Ruhl
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