The University of Southampton
University of Southampton Institutional Repository

Synthesis of new building blocks for use in supramolecular DNA architectures

Synthesis of new building blocks for use in supramolecular DNA architectures
Synthesis of new building blocks for use in supramolecular DNA architectures
New nucleoside building blocks for the synthesis of functional DNA are presented. A porphyrin-bis nucleoside dU-porphyrin-dU was synthesised from a di-acetylene-substituted porphyrin using Sonogashira coupling with 5-iodo deoxy uridine. The same strategy was used to obtain a new terpy-functionalised nucleoside dUterpy. This building block can be metallated with ruthenium(II) either to make a mono-nucleoside ruthenium complex (dUterpy)RuII(terpy), or to connect two building blocks to create a bis-nucleoside (dUterpy)2RuII. The terpy nucleoside building block dUterpy was incorporated into short strands of DNA to give TXT, TXXT and TXXXT as sequences (X = dUterpy). The functionalised DNA has the potential to create supramolecular assemblies through metal complexation
porphyrin, terpy metal complex, nucleoside, DNA scaffold, functional DNA
1061-0278
103-108
Ruhl, Thomas
6cb8b8b2-e4b0-43d9-9ba0-5ef730c6c750
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Ruhl, Thomas
6cb8b8b2-e4b0-43d9-9ba0-5ef730c6c750
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d

Ruhl, Thomas and Stulz, Eugen (2010) Synthesis of new building blocks for use in supramolecular DNA architectures. Supramolecular Chemistry, 22 (2), 103-108. (doi:10.1080/10610270903304418).

Record type: Article

Abstract

New nucleoside building blocks for the synthesis of functional DNA are presented. A porphyrin-bis nucleoside dU-porphyrin-dU was synthesised from a di-acetylene-substituted porphyrin using Sonogashira coupling with 5-iodo deoxy uridine. The same strategy was used to obtain a new terpy-functionalised nucleoside dUterpy. This building block can be metallated with ruthenium(II) either to make a mono-nucleoside ruthenium complex (dUterpy)RuII(terpy), or to connect two building blocks to create a bis-nucleoside (dUterpy)2RuII. The terpy nucleoside building block dUterpy was incorporated into short strands of DNA to give TXT, TXXT and TXXXT as sequences (X = dUterpy). The functionalised DNA has the potential to create supramolecular assemblies through metal complexation

Text
SupramolChem_10.pdf - Other
Restricted to Repository staff only
Request a copy

More information

Published date: 2 February 2010
Keywords: porphyrin, terpy metal complex, nucleoside, DNA scaffold, functional DNA

Identifiers

Local EPrints ID: 145817
URI: http://eprints.soton.ac.uk/id/eprint/145817
ISSN: 1061-0278
PURE UUID: 0d7f779f-5c77-4791-8830-4dd0dfbafb42
ORCID for Eugen Stulz: ORCID iD orcid.org/0000-0002-5302-2276

Catalogue record

Date deposited: 20 Apr 2010 07:22
Last modified: 05 Nov 2019 01:47

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×