Relationship between trait anxiety, prefrontal cortex, and attention bias to angry faces in children and adolescents
Relationship between trait anxiety, prefrontal cortex, and attention bias to angry faces in children and adolescents
Using event-related functional magnetic resonance imaging (fMRI) with a visual-probe task that
assesses attention to threat, we investigated the cognitive and neurophysiological correlates of trait
anxiety in youth. During fMRI acquisition, 16 healthy children and adolescents viewed angry-neutral
face pairs and responded to a probe that was on the same (angry-congruent) or opposite (angryincongruent)
side as the angry face. Attention bias scores were calculated by subtracting participants’
mean reaction time for angry-congruent trials from angry-incongruent trials. Trait anxiety was
positively associated with attention bias towards angry faces. Neurophysiologically, trait anxiety was
positively associated with right dorsolateral prefrontal cortex (PFC) activation on a contrast of trials
that reflect the attention bias for angry faces (i.e., angry-incongruent versus angry-congruent trials).
Trait anxiety was also positively associated with right ventrolateral PFC activation on trials with face
stimuli (versus baseline), irrespective of their emotional content.
functional mri, trait anxiety, prefrontal cortex, attention
216-222
Telzer, Eva H.
38bbf958-6115-470b-93a8-1cec7b7cc024
Mogg, Karin
5f1474af-85f5-4fd3-8eb6-0371be848e30
Bradley, Brendan P.
bdacaa6c-528b-4086-9448-27ebfe463514
Mai, Xiaoqin
74ecf9f7-ceaf-468c-9242-f70650533949
Ernst, Monique
3906e5f6-2105-48af-9b78-a00482acac1c
Pine, Daniel S.
debffc1c-1efc-4bcf-81b3-87aadee1047d
Monk, Christopher S.
ac508cb8-4ce2-4653-a746-be909af175a4
October 2008
Telzer, Eva H.
38bbf958-6115-470b-93a8-1cec7b7cc024
Mogg, Karin
5f1474af-85f5-4fd3-8eb6-0371be848e30
Bradley, Brendan P.
bdacaa6c-528b-4086-9448-27ebfe463514
Mai, Xiaoqin
74ecf9f7-ceaf-468c-9242-f70650533949
Ernst, Monique
3906e5f6-2105-48af-9b78-a00482acac1c
Pine, Daniel S.
debffc1c-1efc-4bcf-81b3-87aadee1047d
Monk, Christopher S.
ac508cb8-4ce2-4653-a746-be909af175a4
Telzer, Eva H., Mogg, Karin, Bradley, Brendan P., Mai, Xiaoqin, Ernst, Monique, Pine, Daniel S. and Monk, Christopher S.
(2008)
Relationship between trait anxiety, prefrontal cortex, and attention bias to angry faces in children and adolescents.
Biological Psychology, 79 (2), .
(doi:10.1016/j.biopsycho.2008.05.004).
(PMID:2574721)
Abstract
Using event-related functional magnetic resonance imaging (fMRI) with a visual-probe task that
assesses attention to threat, we investigated the cognitive and neurophysiological correlates of trait
anxiety in youth. During fMRI acquisition, 16 healthy children and adolescents viewed angry-neutral
face pairs and responded to a probe that was on the same (angry-congruent) or opposite (angryincongruent)
side as the angry face. Attention bias scores were calculated by subtracting participants’
mean reaction time for angry-congruent trials from angry-incongruent trials. Trait anxiety was
positively associated with attention bias towards angry faces. Neurophysiologically, trait anxiety was
positively associated with right dorsolateral prefrontal cortex (PFC) activation on a contrast of trials
that reflect the attention bias for angry faces (i.e., angry-incongruent versus angry-congruent trials).
Trait anxiety was also positively associated with right ventrolateral PFC activation on trials with face
stimuli (versus baseline), irrespective of their emotional content.
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Published date: October 2008
Keywords:
functional mri, trait anxiety, prefrontal cortex, attention
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Local EPrints ID: 145983
URI: http://eprints.soton.ac.uk/id/eprint/145983
ISSN: 0301-0511
PURE UUID: ed37a972-1256-467b-a596-2b57306199b6
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Date deposited: 20 Apr 2010 09:27
Last modified: 14 Mar 2024 02:45
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Contributors
Author:
Eva H. Telzer
Author:
Xiaoqin Mai
Author:
Monique Ernst
Author:
Daniel S. Pine
Author:
Christopher S. Monk
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