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Assessing nonsuperiority, noninferiority, or equivalence when comparing two regression models over a restricted covariate region

Liu, W., Bretz, F., Hayter, A. J. and Wynn, H. P. (2009) Assessing nonsuperiority, noninferiority, or equivalence when comparing two regression models over a restricted covariate region Biometrics, 65, (4), pp. 1279-1287. (doi:10.1111/j.1541-0420.2008.01192.x).

Record type: Article

Abstract

In many scientific problems the purpose of the comparison of two regression models, which describe the relationship between a same response variable and several same covariates for two different groups, is to demonstrate that one model is no higher than the other by a negligible amount, or to demonstrate that the models have only negligible differences and so they can be regarded as describing practically the same relationship between the response variable and the covariates.

In this article, methods based on one-sided pointwise confidence bands are proposed for assessing the nonsuperiority of one model to the other and for assessing the equivalence of two regression models. Examples from QT/QTc study and from drug stability study are used to illustrate the methods.

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Published date: December 2009
Keywords: confidence bands, drug stability study, equivalence, F-tests, hypotheses tests, intersection-union test, nonsuperiority, noninferiority, QT/QTc studies, regression, simultaneous inference
Organisations: Statistics

Identifiers

Local EPrints ID: 146023
URI: http://eprints.soton.ac.uk/id/eprint/146023
PURE UUID: 893c16cc-55c6-45ff-9f60-5204ff411dcf
ORCID for W. Liu: ORCID iD orcid.org/0000-0002-4719-0345

Catalogue record

Date deposited: 20 Apr 2010 11:48
Last modified: 18 Jul 2017 23:05

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Contributors

Author: W. Liu ORCID iD
Author: F. Bretz
Author: A. J. Hayter
Author: H. P. Wynn

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