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[FeFe]-hydrogenase cyanide ligands derived FromS-adenosylmethionine-dependent cleavage of tyrosine

[FeFe]-hydrogenase cyanide ligands derived FromS-adenosylmethionine-dependent cleavage of tyrosine
[FeFe]-hydrogenase cyanide ligands derived FromS-adenosylmethionine-dependent cleavage of tyrosine
What's your poison?

Hydrogenases catalyze the reversible formation of dihydrogen from two electrons and two protons. The maturation of the [FeFe]-hydrogenase active-site cofactor (H cluster) requires three gene products, HydE, HydF, and HydG. Cyanide has been characterized as one of the products of tyrosine cleavage by the S-adenosylmethionine-dependent enzyme HydG, clarifying its role in H-cluster biosynthesis. DOA=deoxyadenosine.
bioinorganic chemistry, biosynthesis, cyanides, hydrogenases, metalloenzymes
1433-7851
1687-1690
Driesener, Rebecca C.
a42528a9-1225-4246-acca-095b99cc9d3e
Challand, Martin R.
03bb1ded-9274-4525-8377-8e5930f30d65
McGlynn, Shawn E.
894be6e2-ef61-43f4-b3fa-077afd7735cb
Shepard, Eric M.
2f916a0e-62bf-410b-bf52-b0756e86365e
Boyd, Eric S.
049410ba-5542-4cd7-868e-10e58702d46a
Broderick, Joan B.
9eb68505-070d-4ba2-a2ad-71c942330a1a
Peters, John W.
84377e0f-e6d8-4e56-aed8-584ec85c28ad
Roach, Peter L.
ca94060c-4443-482b-af3e-979243488ba9
Driesener, Rebecca C.
a42528a9-1225-4246-acca-095b99cc9d3e
Challand, Martin R.
03bb1ded-9274-4525-8377-8e5930f30d65
McGlynn, Shawn E.
894be6e2-ef61-43f4-b3fa-077afd7735cb
Shepard, Eric M.
2f916a0e-62bf-410b-bf52-b0756e86365e
Boyd, Eric S.
049410ba-5542-4cd7-868e-10e58702d46a
Broderick, Joan B.
9eb68505-070d-4ba2-a2ad-71c942330a1a
Peters, John W.
84377e0f-e6d8-4e56-aed8-584ec85c28ad
Roach, Peter L.
ca94060c-4443-482b-af3e-979243488ba9

Driesener, Rebecca C., Challand, Martin R., McGlynn, Shawn E., Shepard, Eric M., Boyd, Eric S., Broderick, Joan B., Peters, John W. and Roach, Peter L. (2010) [FeFe]-hydrogenase cyanide ligands derived FromS-adenosylmethionine-dependent cleavage of tyrosine. Angewandte Chemie International Edition, 49 (9), 1687-1690. (doi:10.1002/anie.200907047).

Record type: Article

Abstract

What's your poison?

Hydrogenases catalyze the reversible formation of dihydrogen from two electrons and two protons. The maturation of the [FeFe]-hydrogenase active-site cofactor (H cluster) requires three gene products, HydE, HydF, and HydG. Cyanide has been characterized as one of the products of tyrosine cleavage by the S-adenosylmethionine-dependent enzyme HydG, clarifying its role in H-cluster biosynthesis. DOA=deoxyadenosine.

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More information

Published date: 27 January 2010
Related URLs:
Keywords: bioinorganic chemistry, biosynthesis, cyanides, hydrogenases, metalloenzymes
Organisations: Chemistry
Learn more about Chemistry research

Identifiers

Local EPrints ID: 146159
URI: http://eprints.soton.ac.uk/id/eprint/146159
DOI: doi:10.1002/anie.200907047
ISSN: 1433-7851
PURE UUID: 8cc3e10b-9a48-4e21-a095-cff87abd69ab
ORCID for Peter L. Roach: ORCID iD orcid.org/0000-0001-9880-2877

Catalogue record

Date deposited: 21 Apr 2010 11:47
Last modified: 14 Mar 2024 00:54

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Contributors

Author: Rebecca C. Driesener
Author: Martin R. Challand
Author: Shawn E. McGlynn
Author: Eric M. Shepard
Author: Eric S. Boyd
Author: Joan B. Broderick
Author: John W. Peters
Author: Peter L. Roach ORCID iD

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