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Cancer Pain: Part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners

Raphael, Jon, Hester, Joan, Ahmedzai, Sam, Barrie, Janette, Farqhuar-Smith, Paul, Williams, John, Urch, Catherine, Bennett, Michael, Robb, Karen, Simpson, Brian, Pittler, Max, Wider, Barbara, Ewer-Smith, Charlie, DeCourcy, James, Young, Ann, Liossi, Christina, McCullough, Renee, Rajapakse, Dilini, Johnson, Martin, Duarte, Rui and Sparkes, Elizabeth (2010) Cancer Pain: Part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners Pain Medicine, 11, (5), pp. 742-764. (doi:10.1111/j.1526-4637.2010.00840.x). (PMID:20546514).

Record type: Article

Abstract

Objective. This discussion document about the management of cancer pain is written from the pain specialists' perspective in order to provoke thought and interest in a multimodal approach to the management of cancer pain, not just towards the end of life, but pain at diagnosis, as a consequence of cancer therapies, and in cancer survivors. It relates the science of pain to the clinical setting and explains the role of psychological, physical, interventional and complementary therapies in cancer pain.

Methods. This document has been produced by a consensus group of relevant health care professionals in the United Kingdom and patients' representatives making reference to the current body of evidence relating to cancer pain. In the first of two parts, pathophysiology, oncological, pharmacological, and psychological treatment are considered.

Conclusions. It is recognized that the World Health Organization (WHO) analgesic ladder, while providing relief of cancer pain towards the end of life for many sufferers worldwide, may have limitations in the context of longer survival and increasing disease complexity. To complement this, it is suggested that a more comprehensive model of managing cancer pain is needed that is mechanism-based and multimodal, using combination therapies including interventions where appropriate, tailored to the needs of an individual, with the aim to optimize pain relief with minimization of adverse effects.

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Submitted date: 8 January 2010
e-pub ahead of print date: 23 April 2010
Published date: May 2010
Keywords: palliative care, pain, neoplasms, therapeutics

Identifiers

Local EPrints ID: 146299
URI: http://eprints.soton.ac.uk/id/eprint/146299
ISSN: 1526-2375
PURE UUID: a8f135f7-dbbc-4ee6-b361-65d41f29e5c3

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Date deposited: 23 Apr 2010 09:41
Last modified: 18 Jul 2017 23:04

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Contributors

Author: Jon Raphael
Author: Joan Hester
Author: Sam Ahmedzai
Author: Janette Barrie
Author: Paul Farqhuar-Smith
Author: John Williams
Author: Catherine Urch
Author: Michael Bennett
Author: Karen Robb
Author: Brian Simpson
Author: Max Pittler
Author: Barbara Wider
Author: Charlie Ewer-Smith
Author: James DeCourcy
Author: Ann Young
Author: Renee McCullough
Author: Dilini Rajapakse
Author: Martin Johnson
Author: Rui Duarte
Author: Elizabeth Sparkes

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