Induced sputum: a window to lung pathology
Induced sputum: a window to lung pathology
Sputum is recognized as a sampling method for the monitoring and assessment of chronic lung diseases such as asthma, COPD (chronic obstructive pulmonary disease) and cystic fibrosis. Sputum samples the central airways and its protein components (e.g. mucins and cytokines), cellular components (e.g. eosinophils and neutrophils) and microbiological components (e.g. viruses and bacteria) can be used as markers of disease severity, exacerbation, susceptibility or progression. This paper describes the basic constituents of induced sputum and how these influence the quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics.
biomarker, chronic lung disease, mucin, proteomics, sputum
868-872
Nicholas, Ben
785c44fb-6536-4189-803b-4545425e9385
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
August 2009
Nicholas, Ben
785c44fb-6536-4189-803b-4545425e9385
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Nicholas, Ben and Djukanovic, Ratko
(2009)
Induced sputum: a window to lung pathology.
Biochemical Society Transactions, 37 (4), .
(doi:10.1042/BST0370868).
Abstract
Sputum is recognized as a sampling method for the monitoring and assessment of chronic lung diseases such as asthma, COPD (chronic obstructive pulmonary disease) and cystic fibrosis. Sputum samples the central airways and its protein components (e.g. mucins and cytokines), cellular components (e.g. eosinophils and neutrophils) and microbiological components (e.g. viruses and bacteria) can be used as markers of disease severity, exacerbation, susceptibility or progression. This paper describes the basic constituents of induced sputum and how these influence the quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics.
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Published date: August 2009
Keywords:
biomarker, chronic lung disease, mucin, proteomics, sputum
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Local EPrints ID: 146347
URI: http://eprints.soton.ac.uk/id/eprint/146347
ISSN: 0300-5127
PURE UUID: 081301d7-f63a-4529-af38-1f717f8ff0b7
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Date deposited: 21 Apr 2010 10:38
Last modified: 14 Mar 2024 02:48
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Author:
Ben Nicholas
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