Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study.
Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study.
Background:
Asthma is considered to be associated with elevated levels of exhaled nitric oxide (FeNO). The nature of this relationship and how it is influenced by atopy are still not resolved.
Methods:
The Isle of Wight birth cohort (N=1456) was reassessed at 18 years of age. Participants able to attend the research centre were assessed by questionnaires, skin prick testing and FeNO in order to explore the interrelationship between asthma, atopy and FeNO.
Results:
Atopy was significantly associated with higher levels of FeNO. However, the level of FeNO for non-atopic asthmatic participants was no different to the non-atopic no-asthma group. The highest levels of FeNO were seen in subjects with both atopy and asthma. In addition, FeNO was positively associated with increasing atopic burden as evidenced by increasing FeNO with increasing skin prick testing positivity, and with increasing severity of atopic asthma as evidenced by the number of attacks of wheezing. FeNO and current inhaled corticosteroid use were not significantly associated.
Conclusions:
FeNO behaves as a biomarker of atopy and the "allergic asthma" phenotype rather than asthma itself. This may explain why FeNO-guided asthma treatment outcomes have proved to be of limited success where atopic status has not been considered and accounted for.
258-262
Scott, Martha
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Raza, Abid
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Karmaus, Wilfried
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Mitchell, Frances
74275354-246c-4ea2-bb7a-e6ed2dfa0833
Grundy, Jane
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Kurukulaaratchy, Ramesh J.
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Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
March 2010
Scott, Martha
e4164678-f688-4d10-bc35-b89b4c944ab3
Raza, Abid
bba8b06c-46af-4f7e-acf5-26dba73fc5f3
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Mitchell, Frances
74275354-246c-4ea2-bb7a-e6ed2dfa0833
Grundy, Jane
f8d6ced1-b9ab-4ee9-aa14-2f2805597fbe
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Scott, Martha, Raza, Abid, Karmaus, Wilfried, Mitchell, Frances, Grundy, Jane, Kurukulaaratchy, Ramesh J., Arshad, S. Hasan and Roberts, Graham
(2010)
Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study.
Thorax, 65 (3), .
(doi:10.1136/thx.2009.125443).
Abstract
Background:
Asthma is considered to be associated with elevated levels of exhaled nitric oxide (FeNO). The nature of this relationship and how it is influenced by atopy are still not resolved.
Methods:
The Isle of Wight birth cohort (N=1456) was reassessed at 18 years of age. Participants able to attend the research centre were assessed by questionnaires, skin prick testing and FeNO in order to explore the interrelationship between asthma, atopy and FeNO.
Results:
Atopy was significantly associated with higher levels of FeNO. However, the level of FeNO for non-atopic asthmatic participants was no different to the non-atopic no-asthma group. The highest levels of FeNO were seen in subjects with both atopy and asthma. In addition, FeNO was positively associated with increasing atopic burden as evidenced by increasing FeNO with increasing skin prick testing positivity, and with increasing severity of atopic asthma as evidenced by the number of attacks of wheezing. FeNO and current inhaled corticosteroid use were not significantly associated.
Conclusions:
FeNO behaves as a biomarker of atopy and the "allergic asthma" phenotype rather than asthma itself. This may explain why FeNO-guided asthma treatment outcomes have proved to be of limited success where atopic status has not been considered and accounted for.
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More information
Published date: March 2010
Organisations:
Infection Inflammation & Immunity
Identifiers
Local EPrints ID: 146365
URI: http://eprints.soton.ac.uk/id/eprint/146365
ISSN: 0040-6376
PURE UUID: dc446660-a1b8-400d-a4de-bd1f1df5d743
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Date deposited: 21 Apr 2010 11:05
Last modified: 14 Mar 2024 02:50
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Author:
Martha Scott
Author:
Abid Raza
Author:
Wilfried Karmaus
Author:
Frances Mitchell
Author:
Jane Grundy
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