Ossifying fibromyxoid tumour of the sphenoid sinus
Ossifying fibromyxoid tumour of the sphenoid sinus
Introduction: Ossifying fibromyxoid tumour is a recently described, rare but morphologically distinctive soft tissue neoplasm characterised by a combination of myxoid and/or fibrous stroma with areas of ossification. Although most authors postulate a neuroectodermal origin for this peculiar tumour, there is no agreement in the literature regarding its histopathogenesis. To our knowledge, this is the first reported case of ossifying fibromyxoid tumour involving the sphenoid sinus.
Histological findings: Tumour of low cell density, composed of small, spindle-shaped or stellate cells with small, irregular nuclei set in a fibromyxoid stroma.
Management: Following discussion at the skull base multidisciplinary team meeting, a combined surgical team including an otorhinolaryngologist and a neurosurgeon carried out resection of the lesion, using an endoscopic transnasal approach, followed by reconstruction of the defect.
Conclusions: An awareness of the distinctive histopathological features of ossifying fibromyxoid tumour, and of its clinical effects, is crucial to establishing a definitive diagnosis and thereby instituting appropriate management. This case report also reinforces the evolving role of the endoscopic transnasal approach in the management of inflammatory and neoplastic disease involving the skull base. This is increasingly being made possible by close collaboration between multiple surgical specialties, including otorhinolaryngology and neurosurgery.
nasal, paranasal sinuses, tumour, skull base, pathology, treatment, endoscopic surgery
437-440
Shetty, S.D.
c95f6091-6a7e-4439-bff7-679aad152fb3
Salib, R.J.
d6fde1c1-5b5e-43f7-ae1c-42cce6a0c9fc
Nair, S.B.
953b5873-c37e-4136-92c7-9af6809cee43
Mathad, N.
0bab0cea-8883-4477-b1a3-d8b822a1e78f
Theaker, J.
ce2bf492-c255-453a-a6e8-ae521956474d
April 2010
Shetty, S.D.
c95f6091-6a7e-4439-bff7-679aad152fb3
Salib, R.J.
d6fde1c1-5b5e-43f7-ae1c-42cce6a0c9fc
Nair, S.B.
953b5873-c37e-4136-92c7-9af6809cee43
Mathad, N.
0bab0cea-8883-4477-b1a3-d8b822a1e78f
Theaker, J.
ce2bf492-c255-453a-a6e8-ae521956474d
Shetty, S.D., Salib, R.J., Nair, S.B., Mathad, N. and Theaker, J.
(2010)
Ossifying fibromyxoid tumour of the sphenoid sinus.
Journal of Laryngology & Otology, 124 (4), .
(doi:10.1017/S0022215109991289).
Abstract
Introduction: Ossifying fibromyxoid tumour is a recently described, rare but morphologically distinctive soft tissue neoplasm characterised by a combination of myxoid and/or fibrous stroma with areas of ossification. Although most authors postulate a neuroectodermal origin for this peculiar tumour, there is no agreement in the literature regarding its histopathogenesis. To our knowledge, this is the first reported case of ossifying fibromyxoid tumour involving the sphenoid sinus.
Histological findings: Tumour of low cell density, composed of small, spindle-shaped or stellate cells with small, irregular nuclei set in a fibromyxoid stroma.
Management: Following discussion at the skull base multidisciplinary team meeting, a combined surgical team including an otorhinolaryngologist and a neurosurgeon carried out resection of the lesion, using an endoscopic transnasal approach, followed by reconstruction of the defect.
Conclusions: An awareness of the distinctive histopathological features of ossifying fibromyxoid tumour, and of its clinical effects, is crucial to establishing a definitive diagnosis and thereby instituting appropriate management. This case report also reinforces the evolving role of the endoscopic transnasal approach in the management of inflammatory and neoplastic disease involving the skull base. This is increasingly being made possible by close collaboration between multiple surgical specialties, including otorhinolaryngology and neurosurgery.
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Published date: April 2010
Keywords:
nasal, paranasal sinuses, tumour, skull base, pathology, treatment, endoscopic surgery
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Local EPrints ID: 146577
URI: http://eprints.soton.ac.uk/id/eprint/146577
PURE UUID: 515253a2-9dcd-498c-a84d-694b68b889da
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Date deposited: 21 Apr 2010 14:27
Last modified: 14 Mar 2024 02:47
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Author:
S.D. Shetty
Author:
S.B. Nair
Author:
N. Mathad
Author:
J. Theaker
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