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Platform for controlled supramolecular nanoassembly

Platform for controlled supramolecular nanoassembly
Platform for controlled supramolecular nanoassembly
We here present a two-dimensional (2D) micro/nano-fluidic technique where reactant-doped liquid?crystal films spread and mix on micro- and nanopatterned substrates. Surface-supported phospholipid monolayers are individually doped with complementary DNA molecules which hybridize when these lipid films mix.

Using lipid films to convey reactants reduces the dimensionality of traditional 3D chemistry to 2D, and possibly to 1D by confining the lipid film to nanometer-sized lanes. The hybridization event was observed by FRET using single-molecule-sensitive confocal fluorescence detection. We could successfully detect hybridization in lipid streams on 250 nm wide lanes. Our results show that the number and density of reactants as well as sequence of reactant addition can be controlled within confined liquid crystal films, providing a platform for nanochemistry with potential for kinetic control.
1530-6984
2482-2486
Czolkos, Ilja
04418544-9c17-4993-9779-ac7ed9c3a6c6
Hannestad, Jonas K.
59a727a0-ab44-4eb1-9ab5-7e1fc57cb9e9
Jesorka, Aldo
2c99fa24-a8da-42fa-8847-fc5a689818e3
Kumar, Ravindra
dfd53d15-f740-4a18-90ad-efa6f2c5e488
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Albinsson, Bo
1571067f-df46-43f7-96b9-52dc43278777
Orwar, Owe
507d5098-e27d-4d04-ba76-a8173bdbf7ea
Czolkos, Ilja
04418544-9c17-4993-9779-ac7ed9c3a6c6
Hannestad, Jonas K.
59a727a0-ab44-4eb1-9ab5-7e1fc57cb9e9
Jesorka, Aldo
2c99fa24-a8da-42fa-8847-fc5a689818e3
Kumar, Ravindra
dfd53d15-f740-4a18-90ad-efa6f2c5e488
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Albinsson, Bo
1571067f-df46-43f7-96b9-52dc43278777
Orwar, Owe
507d5098-e27d-4d04-ba76-a8173bdbf7ea

Czolkos, Ilja, Hannestad, Jonas K., Jesorka, Aldo, Kumar, Ravindra, Brown, Tom, Albinsson, Bo and Orwar, Owe (2009) Platform for controlled supramolecular nanoassembly. Nano Letters, 9 (6), 2482-2486. (doi:10.1021/nl901254f).

Record type: Article

Abstract

We here present a two-dimensional (2D) micro/nano-fluidic technique where reactant-doped liquid?crystal films spread and mix on micro- and nanopatterned substrates. Surface-supported phospholipid monolayers are individually doped with complementary DNA molecules which hybridize when these lipid films mix.

Using lipid films to convey reactants reduces the dimensionality of traditional 3D chemistry to 2D, and possibly to 1D by confining the lipid film to nanometer-sized lanes. The hybridization event was observed by FRET using single-molecule-sensitive confocal fluorescence detection. We could successfully detect hybridization in lipid streams on 250 nm wide lanes. Our results show that the number and density of reactants as well as sequence of reactant addition can be controlled within confined liquid crystal films, providing a platform for nanochemistry with potential for kinetic control.

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More information

Published date: 7 May 2009

Identifiers

Local EPrints ID: 146673
URI: http://eprints.soton.ac.uk/id/eprint/146673
ISSN: 1530-6984
PURE UUID: 4576e374-6e06-4ece-bc6e-050c536a3e2a

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Date deposited: 22 Apr 2010 08:33
Last modified: 17 Jul 2019 00:04

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Contributors

Author: Ilja Czolkos
Author: Jonas K. Hannestad
Author: Aldo Jesorka
Author: Ravindra Kumar
Author: Tom Brown
Author: Bo Albinsson
Author: Owe Orwar

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