A very stable cyclic DNA miniduplex with just two base pairs
A very stable cyclic DNA miniduplex with just two base pairs
Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circular dichroism indicates that the bases are stacked, and UV melting and NMR spectroscopy showed that the interbase hydrogen bonds are very stable, even in a dimer.
cyclic, dna recognition, dna structure, dna, miniduplex
50-52
El-Sagheer, Afaf H.
0bf56d90-78ee-4772-add8-453ccacc39be
Kumar, Ravindra
dfd53d15-f740-4a18-90ad-efa6f2c5e488
Findlow, Stuart C.
0a7193ad-45cf-4613-a35e-3fd019a92ebe
Werner, Joern M.
1b02513a-8310-4f4f-adac-dc2a466bd115
Lane, Andrew N.
45ad386f-2308-4610-998b-7913fa4d457c
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
4 January 2008
El-Sagheer, Afaf H.
0bf56d90-78ee-4772-add8-453ccacc39be
Kumar, Ravindra
dfd53d15-f740-4a18-90ad-efa6f2c5e488
Findlow, Stuart C.
0a7193ad-45cf-4613-a35e-3fd019a92ebe
Werner, Joern M.
1b02513a-8310-4f4f-adac-dc2a466bd115
Lane, Andrew N.
45ad386f-2308-4610-998b-7913fa4d457c
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
El-Sagheer, Afaf H., Kumar, Ravindra, Findlow, Stuart C., Werner, Joern M., Lane, Andrew N. and Brown, Tom
(2008)
A very stable cyclic DNA miniduplex with just two base pairs.
ChemBioChem, 9 (1), .
(doi:10.1002/cbic.200700538).
(PMID:18058775)
Abstract
Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circular dichroism indicates that the bases are stacked, and UV melting and NMR spectroscopy showed that the interbase hydrogen bonds are very stable, even in a dimer.
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More information
e-pub ahead of print date: 30 November 2007
Published date: 4 January 2008
Keywords:
cyclic, dna recognition, dna structure, dna, miniduplex
Identifiers
Local EPrints ID: 146717
URI: http://eprints.soton.ac.uk/id/eprint/146717
ISSN: 1439-4227
PURE UUID: da1a65e5-4478-403a-8775-20464b9ba3cd
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Date deposited: 22 Apr 2010 09:34
Last modified: 14 Mar 2024 02:48
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Contributors
Author:
Afaf H. El-Sagheer
Author:
Ravindra Kumar
Author:
Stuart C. Findlow
Author:
Andrew N. Lane
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