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Spatial predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda

Spatial predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda
Spatial predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda
The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda.
1935-2727
1-11
Batchelor, Nicola A
8f3a8171-0727-4375-bc68-10e7d616e176
Atkinson, P.M.
96e96579-56fe-424d-a21c-17b6eed13b0b
Gething, Peter W
f8e80d09-acc3-4f5d-a2de-bff551f34760
Picozzi, Kim
fd3ebedb-971d-4931-b0f2-90197fe04cae
Fèvre, Eric M
d1fc8e05-7138-4a8d-bdcb-0cb8eb6bb6a3
Kakembo, Abbas S L
b7deca04-0afd-4866-b5a2-74b4e408eb48
Welburn, Susan C
531d82a4-0190-4ff9-a7bb-576ae38fa0b3
Batchelor, Nicola A
8f3a8171-0727-4375-bc68-10e7d616e176
Atkinson, P.M.
96e96579-56fe-424d-a21c-17b6eed13b0b
Gething, Peter W
f8e80d09-acc3-4f5d-a2de-bff551f34760
Picozzi, Kim
fd3ebedb-971d-4931-b0f2-90197fe04cae
Fèvre, Eric M
d1fc8e05-7138-4a8d-bdcb-0cb8eb6bb6a3
Kakembo, Abbas S L
b7deca04-0afd-4866-b5a2-74b4e408eb48
Welburn, Susan C
531d82a4-0190-4ff9-a7bb-576ae38fa0b3

Batchelor, Nicola A, Atkinson, P.M., Gething, Peter W, Picozzi, Kim, Fèvre, Eric M, Kakembo, Abbas S L and Welburn, Susan C (2009) Spatial predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda. PLoS Neglected Tropical Diseases, 3 (12), 1-11. (doi:10.1371/journal.pntd.0000563).

Record type: Article

Abstract

The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda.

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Published date: December 2009
Additional Information: PLoS Public Library of Science
Organisations: Geography, Geography & Environment, PHEW – P (Population Health), PHEW – S (Spatial analysis and modelling), Population, Health & Wellbeing (PHeW)

Identifiers

Local EPrints ID: 146757
URI: https://eprints.soton.ac.uk/id/eprint/146757
ISSN: 1935-2727
PURE UUID: b3051212-beaa-4350-83d6-782601406291
ORCID for P.M. Atkinson: ORCID iD orcid.org/0000-0002-5489-6880

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Date deposited: 22 Apr 2010 12:50
Last modified: 20 Jul 2019 01:20

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Contributors

Author: P.M. Atkinson ORCID iD
Author: Peter W Gething
Author: Kim Picozzi
Author: Eric M Fèvre
Author: Abbas S L Kakembo
Author: Susan C Welburn

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