The t(14;20) is a poor prognostic factor in myeloma but is associated with long term stable disease in MGUS
The t(14;20) is a poor prognostic factor in myeloma but is associated with long term stable disease in MGUS
A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behaviour was compared to a group characterised by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148, <1%) with a higher incidence in MGUS (9/193, 5% p=0.005).
Strong associations with del(13) (76%), nonhyperdiploidy (83%) and gain of 1q (58%) were seen but no association with an IgA M-protein or absence of bone disease was noted. All three translocations were associated with poor outcome in myeloma, but strikingly all t(14;20) MGUS/smouldering myeloma cases (n=10) had stable, low level disease. In contrast, the 10 t(14;16) and 25 t(4;14), MGUS/smoldering myeloma cases were associated with both evolving and non-evolving disease. None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma.
monoclonal gammopathy of undetermined significance, multiple myeloma, cytogenetics and molecular genetics, disease progression
1221-1225
Ross, Fiona M.
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Chiecchio, Laura
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Dagrada, GianPaolo
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Protheroe, Rebecca K.M.
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Stockley, David M.
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Harrison, Christine J.
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Cross, Nicholas C.P.
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Szubert, Alex J.
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Drayson, Mark T.
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Morgan, Gareth J.
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July 2010
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Chiecchio, Laura
3d2f63e3-3df1-4655-8478-00ecd89d009c
Dagrada, GianPaolo
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Protheroe, Rebecca K.M.
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Stockley, David M.
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Harrison, Christine J.
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Cross, Nicholas C.P.
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Szubert, Alex J.
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Drayson, Mark T.
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Morgan, Gareth J.
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Ross, Fiona M., Chiecchio, Laura, Dagrada, GianPaolo, Protheroe, Rebecca K.M., Stockley, David M., Harrison, Christine J., Cross, Nicholas C.P., Szubert, Alex J., Drayson, Mark T. and Morgan, Gareth J.
(2010)
The t(14;20) is a poor prognostic factor in myeloma but is associated with long term stable disease in MGUS.
Haematologica, 95 (7), .
(doi:10.3324/haematol.2009.016329).
Abstract
A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behaviour was compared to a group characterised by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148, <1%) with a higher incidence in MGUS (9/193, 5% p=0.005).
Strong associations with del(13) (76%), nonhyperdiploidy (83%) and gain of 1q (58%) were seen but no association with an IgA M-protein or absence of bone disease was noted. All three translocations were associated with poor outcome in myeloma, but strikingly all t(14;20) MGUS/smouldering myeloma cases (n=10) had stable, low level disease. In contrast, the 10 t(14;16) and 25 t(4;14), MGUS/smoldering myeloma cases were associated with both evolving and non-evolving disease. None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma.
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Accepted/In Press date: 21 April 2010
Published date: July 2010
Keywords:
monoclonal gammopathy of undetermined significance, multiple myeloma, cytogenetics and molecular genetics, disease progression
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Local EPrints ID: 147321
URI: http://eprints.soton.ac.uk/id/eprint/147321
ISSN: 0390-6078
PURE UUID: de455d7d-44e2-40dd-92b2-0994eebf5424
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Date deposited: 23 Apr 2010 13:41
Last modified: 14 Mar 2024 02:46
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Author:
Fiona M. Ross
Author:
Laura Chiecchio
Author:
GianPaolo Dagrada
Author:
Rebecca K.M. Protheroe
Author:
David M. Stockley
Author:
Christine J. Harrison
Author:
Alex J. Szubert
Author:
Mark T. Drayson
Author:
Gareth J. Morgan
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