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Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer
Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, ?v?6 integrin, the laminin-5 ?2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8, -9, -20, and -28 were analysed. The expression of MMP-8 (collagenase-2) was positively associated with improved survival of the patients and the tendency was particularly prominent in females. No sufficient evidence for a correlation with the clinical outcome was found for any other immunohistological marker. To test the protective role of MMP-8 in tongue carcinogenesis, MMP-8 knockout mice were used. MMP-8 deficient female mice developed tongue SCCs at a significantly higher incidence than wild-type mice exposed to carcinogen 4-Nitroquinoline-N-oxide. Consistently, oestrogen-induced MMP-8 expression in cultured HSC-3 tongue carcinoma cells, and MMP-8 cleaved oestrogen receptor (ER) ? and ?. According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.
0007-0920
766-775
Korpi, J.T.
c9088915-c5a6-4c1c-a40c-2144051dd8c6
Kervinen, V.
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Mäklin, H.
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Väänänen, A.
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Lahtinen, M.
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Läärä, E.
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Ristimaki, A.
c4b82fdc-1125-49be-aae9-8adc75f66a16
Thomas, G.
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Ylipalosaari, M.
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Åström, P.
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Lopez-Otin, C.
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Sorsa, T.
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Kantola, S.
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Pirilä, E.
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Salo, T.
da6fc40c-a1ec-4cca-985a-374eeb55c846
Korpi, J.T.
c9088915-c5a6-4c1c-a40c-2144051dd8c6
Kervinen, V.
c07ca719-e03b-4dc8-b419-209cfbf67801
Mäklin, H.
3e30ddd3-6e80-45df-89e2-3bcf492b49dd
Väänänen, A.
b45083d5-cfd7-460f-a490-17549e27a6a2
Lahtinen, M.
91e81f39-1722-46f0-95f3-2da5186e7672
Läärä, E.
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Ristimaki, A.
c4b82fdc-1125-49be-aae9-8adc75f66a16
Thomas, G.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Ylipalosaari, M.
30d4d7fe-3584-4813-bc4c-96463b7c89ef
Åström, P.
4c4be695-5e3f-4bcf-9143-3ab6c1f9ec5b
Lopez-Otin, C.
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Sorsa, T.
24b57e55-74ea-469a-9a00-ddf9aba693ca
Kantola, S.
23c312e6-78a1-4f66-b0cd-3b36ff0c3537
Pirilä, E.
94292f13-a98b-4b2e-b981-405ada6e5143
Salo, T.
da6fc40c-a1ec-4cca-985a-374eeb55c846

Korpi, J.T., Kervinen, V., Mäklin, H., Väänänen, A., Lahtinen, M., Läärä, E., Ristimaki, A., Thomas, G., Ylipalosaari, M., Åström, P., Lopez-Otin, C., Sorsa, T., Kantola, S., Pirilä, E. and Salo, T. (2008) Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer. British Journal of Cancer, 98 (4), 766-775. (doi:10.1038/sj.bjc.6604239).

Record type: Article

Abstract

Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, ?v?6 integrin, the laminin-5 ?2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8, -9, -20, and -28 were analysed. The expression of MMP-8 (collagenase-2) was positively associated with improved survival of the patients and the tendency was particularly prominent in females. No sufficient evidence for a correlation with the clinical outcome was found for any other immunohistological marker. To test the protective role of MMP-8 in tongue carcinogenesis, MMP-8 knockout mice were used. MMP-8 deficient female mice developed tongue SCCs at a significantly higher incidence than wild-type mice exposed to carcinogen 4-Nitroquinoline-N-oxide. Consistently, oestrogen-induced MMP-8 expression in cultured HSC-3 tongue carcinoma cells, and MMP-8 cleaved oestrogen receptor (ER) ? and ?. According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.

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Published date: 26 February 2008

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Local EPrints ID: 147353
URI: http://eprints.soton.ac.uk/id/eprint/147353
ISSN: 0007-0920
PURE UUID: 3d687cbc-3e08-4274-8320-c10d7fdd87ec

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Date deposited: 23 Apr 2010 15:03
Last modified: 14 Mar 2024 00:58

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Contributors

Author: J.T. Korpi
Author: V. Kervinen
Author: H. Mäklin
Author: A. Väänänen
Author: M. Lahtinen
Author: E. Läärä
Author: A. Ristimaki
Author: G. Thomas
Author: M. Ylipalosaari
Author: P. Åström
Author: C. Lopez-Otin
Author: T. Sorsa
Author: S. Kantola
Author: E. Pirilä
Author: T. Salo

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