Rapid sequencing of split-and-mix peptide receptor libraries: Identification of binding partners for Val-Val-Ile-Ala in aqueous solution
Rapid sequencing of split-and-mix peptide receptor libraries: Identification of binding partners for Val-Val-Ile-Ala in aqueous solution
Split-and-mix peptide libraries have been encoded by capping cleavable, laddered sequences with p-bromobenzoic acid, allowing rapid analysis of the cleaved ladder fragments by mass spectrometry. The encoding methodology has been applied to the synthesis of libraries of peptide receptors and a library of tripeptides functionalised with a bicyclic guanidinium unit has been successfully screened to identify binding partners for Val-Val-Ile-Ala, the C-terminal tetrapeptide sequence of the amyloid- protein, A(1-42).
peptides, coding, sequencing, combinatorial chemistry, receptors, screening
1345-1356
Shepherd, Jon
fb416f96-4326-4cff-bfa7-02fc55c4d90e
Langley, G. John
7ac80d61-b91d-4261-ad17-255f94ea21ea
Herniman, Julie M.
530b1a36-1386-4602-8df7-defa6eb3512b
Kilburn, Jeremy D.
e64ded70-825a-40ec-816b-c4605e007e7a
10 January 2007
Shepherd, Jon
fb416f96-4326-4cff-bfa7-02fc55c4d90e
Langley, G. John
7ac80d61-b91d-4261-ad17-255f94ea21ea
Herniman, Julie M.
530b1a36-1386-4602-8df7-defa6eb3512b
Kilburn, Jeremy D.
e64ded70-825a-40ec-816b-c4605e007e7a
Shepherd, Jon, Langley, G. John, Herniman, Julie M. and Kilburn, Jeremy D.
(2007)
Rapid sequencing of split-and-mix peptide receptor libraries: Identification of binding partners for Val-Val-Ile-Ala in aqueous solution.
European Journal of Organic Chemistry, 2007 (8), .
(doi:10.1002/ejoc.200601004).
Abstract
Split-and-mix peptide libraries have been encoded by capping cleavable, laddered sequences with p-bromobenzoic acid, allowing rapid analysis of the cleaved ladder fragments by mass spectrometry. The encoding methodology has been applied to the synthesis of libraries of peptide receptors and a library of tripeptides functionalised with a bicyclic guanidinium unit has been successfully screened to identify binding partners for Val-Val-Ile-Ala, the C-terminal tetrapeptide sequence of the amyloid- protein, A(1-42).
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Published date: 10 January 2007
Keywords:
peptides, coding, sequencing, combinatorial chemistry, receptors, screening
Identifiers
Local EPrints ID: 147773
URI: http://eprints.soton.ac.uk/id/eprint/147773
ISSN: 1434-193X
PURE UUID: 28555f38-9178-4762-a842-717c92253d3f
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Date deposited: 03 Jun 2010 13:22
Last modified: 14 Mar 2024 02:42
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Author:
Jon Shepherd
Author:
Jeremy D. Kilburn
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